Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[ 4,3-b] indoles Using Copper Catalysis
文献类型：期刊论文
| 作者 | Liu, Hailong1,2; Zhang, Lei1; Zhao, Fei1; Liu, Hong1,2
|
| 刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2014-02 |
| 卷号 | 2014期号:5页码:1047-1052 |
| 关键词 | Synthetic methods Cyclization Nitrogen heterocycles Copper Microwave chemistry |
| ISSN号 | 1434-193X |
| DOI | 10.1002/ejoc.201301380 |
| 文献子类 | Article |
| 英文摘要 | A convenient three-step one-pot copper-catalysed method has been developed for the preparation of pyrazolo[4,3-b]indoles, new indole-based compounds with potential biological activity. Treatment of various hydrazines, including alkyl hydrazines, with indole-2-carbaldehydes generated the corresponding products in moderate to good yields without protection of the indole N-1 moiety. In addition, LiOH was used as a base in the copper-catalysed coupling reaction. Microwave heating was used to accelerate the iodination of indoles and the C-N bond formation. |
| WOS关键词 | CROSS-COUPLING REACTIONS ; ARYL IODIDES ; N-ARYLATION ; EFFICIENT APPROACH ; 1-ARYL-1H-INDAZOLES ; HETEROCYCLES ; ANALOGS ; AMINES |
| 资助项目 | National Natural Science Foundation of China (NSFC)[91229204] ; National Natural Science Foundation of China (NSFC)[81025017] ; National S&T Major Projects[2012ZX09103101-072] ; National S&T Major Projects[2012ZX09301001-005] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000331266600016 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277204]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Hailong,Zhang, Lei,Zhao, Fei,et al. Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[ 4,3-b] indoles Using Copper Catalysis[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014,2014(5):1047-1052. |
| APA | Liu, Hailong,Zhang, Lei,Zhao, Fei,&Liu, Hong.(2014).Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[ 4,3-b] indoles Using Copper Catalysis.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2014(5),1047-1052. |
| MLA | Liu, Hailong,et al."Three-Step One-Pot Synthesis of 1,4-Dihydropyrazolo[ 4,3-b] indoles Using Copper Catalysis".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2014.5(2014):1047-1052. |
入库方式： OAI收割
来源：上海药物研究所
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