A heteropolysaccharide, L-fuco-D-manno-1,6-alpha-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative
文献类型：期刊论文
| 作者 | Wang, Ying3; Shen, Xiaokun1,2; Liao, Wenfeng3; Fang, Jianping3; Chen, Xia3; Dong, Qun3; Ding, Kan3
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| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2014-01-30 |
| 卷号 | 101页码:631-641 |
| 关键词 | Grifola frondosa Galactan Antiangiogenesis Human microvascular endothelial cell line-1 (HMEC-1) |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2013.09.085 |
| 文献子类 | Article |
| 英文摘要 | The tumor growth and metastasis are angiogenesis dependent, thus blockade of angiogenesis is a promising approach for treatment of cancer. Herein we reported the structural and biological features of a novel water-soluble polysaccharide named GFPW from the fruit body of Grifola frondosa. Chemical and spectral analysis revealed that GFPW with an average molecular weight of 15.7 kDa, possessed a backbone consisting of alpha-1,6-linked galactopyranosyl residues, with branches attached to O-2 of alpha-1,3-linked fucose residues and alpha-terminal mannose. By the chlorosulfonic acid-pyridine method, we prepared a sulfated derivative of GFPW, Sul-GFPW, with a substitution degree of 0.33. According to the C-13 NMR spectrum, the substitution position was deduced at C-2 and C-3. The angiogenesis assays in vitro showed that Sul-GFPW significantly inhibited endothelial cell proliferation in a dose- and time-dependent manner, and reduced endothelial cell migration and tube formation as well. (C) 2013 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MANNO-D-GLUCAN ; STRUCTURAL-CHARACTERIZATION ; MICROELLOBOSPORIA-GRISEA ; ANTITUMOR-ACTIVITY ; PLATYCODON-GRANDIFLORUM ; PLEUROTUS-OSTREATUS ; GANODERMA-LUCIDUM ; FRUITING BODIES ; IN-VITRO ; POLYSACCHARIDE |
| 资助项目 | National Natural Science Foundation of China[81171914] ; National Natural Science Foundation of China[31230022] ; National Natural Science Foundation of China[81202103] ; National Science Fund for Distinguished Young Scholars in China[81125025] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; Industry-University-Research Institute Alliance Fund in Guangdong Province, China[2010A090200041] |
| WOS研究方向 | Chemistry ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000330494800079 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277216]  |
| 专题 | 药理学第三研究室 药物化学研究室 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Zhejiang Univ, Dept Med, Hangzhou 310029, Zhejiang, Peoples R China 2.Wenzhou Med Coll, Dept Oncol, Linhai 317000, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Ying,Shen, Xiaokun,Liao, Wenfeng,et al. A heteropolysaccharide, L-fuco-D-manno-1,6-alpha-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative[J]. CARBOHYDRATE POLYMERS,2014,101:631-641. |
| APA | Wang, Ying.,Shen, Xiaokun.,Liao, Wenfeng.,Fang, Jianping.,Chen, Xia.,...&Ding, Kan.(2014).A heteropolysaccharide, L-fuco-D-manno-1,6-alpha-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative.CARBOHYDRATE POLYMERS,101,631-641. |
| MLA | Wang, Ying,et al."A heteropolysaccharide, L-fuco-D-manno-1,6-alpha-D-galactan extracted from Grifola frondosa and antiangiogenic activity of its sulfated derivative".CARBOHYDRATE POLYMERS 101(2014):631-641. |
入库方式： OAI收割
来源：上海药物研究所
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