Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation
文献类型：期刊论文
| 作者 | Chen, Guohua1; Yin, Qiang1,3; Yin, Jian2; Gu, Xiangying1,3; Liu, Xiao1,3; You, Qidong1; Chen, Yue-Lei3 ; Xiong, Bing3; Shen, Jingkang3
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| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2014 |
| 卷号 | 12期号:48页码:9781-9785 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c4ob01807a |
| 文献子类 | Article |
| 英文摘要 | For the first time, we demonstrated that Tf2O mediated direct dehydrative glycosylation was possible simply with strained olefins, and other typical bases were inhibitors of this reaction. We optimized the glycosylation conditions and found that typical benzyl protected 1-OH pyranosyl donors and certain alcohol acceptors were suitable for our glycosylation system. Furthermore, we found that complete 1,2-trans selectivity and a wider acceptor scope could be achieved with 2-O-Bz 3,4,6-tri-O-Bn pyranosyl donors. |
| WOS关键词 | ANOMERIC HYDROXY SUGARS ; TRIFLUOROMETHANESULFONIC ANHYDRIDE ; SULFOXIDE ; DONORS ; ACTIVATION ; REAGENT ; 2-DEOXY-SUGARS ; INSTALLATION ; GLYCOSIDES ; STRATEGY |
| 资助项目 | National Natural Science Foundation of China[81102306] ; National Natural Science Foundation of China[21302068] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2014ZX09507-002] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000345458700008 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277257]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Chen, Guohua |
| 作者单位 | 1.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China; 2.Jiangnan Univ, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Sch Biotechnol, Wuxi 214122, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, Guohua,Yin, Qiang,Yin, Jian,et al. Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2014,12(48):9781-9785. |
| APA | Chen, Guohua.,Yin, Qiang.,Yin, Jian.,Gu, Xiangying.,Liu, Xiao.,...&Shen, Jingkang.(2014).Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation.ORGANIC & BIOMOLECULAR CHEMISTRY,12(48),9781-9785. |
| MLA | Chen, Guohua,et al."Strained olefin enables triflic anhydride mediated direct dehydrative glycosylation".ORGANIC & BIOMOLECULAR CHEMISTRY 12.48(2014):9781-9785. |
入库方式： OAI收割
来源：上海药物研究所
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