DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test
文献类型：期刊论文
| 作者 | Li, Kui1,3; Liu, Ji-Wei3; Zhu, Zhi-Chuan3; Wang, Hong-Tao3; Zu, Yong3; Liu, Yong-Jie3; Yang, Yan-Hong3; Xiong, Zhi-Qi3; Shen, Xu1 ; Chen, Rui2
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| 刊名 | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
 |
| 出版日期 | 2014 |
| 卷号 | 7期号:10页码:6486-6492 |
| ISSN号 | 1936-2625 |
| 关键词 | DSTYK knockout mice brain development learning and memory |
| 文献子类 | Article |
| 英文摘要 | DSTYK (Dual serine/threonine and tyrosine protein kinase) is a putative dual Ser/Thr and Tyr protein kinase with unique structural features. It is proposed that DSTYK may play important roles in brain because of its high expression in most brain areas. In the present study, a DSTYK knockout (KO) mouse line with the ablation of C-terminal of DSTYK including the kinase domain was generated to study the physiological function of DSTYK. The DSTYK KO mice are fertile and have no significant morphological defects revealed by Nissl staining compared with wildtype mice. Open field test and rotarod test showed there is no obvious difference in basic motor and balance capacity between the DSTYK homozygous KO mice and DSTYK heterozygous KO mice. In water maze test, however, the DSTYK homozygous KO mice show impaired capabilities of learning and memory compared with the DSTYK heterozygous KO mice. |
| 资助项目 | NICHD NIH HHS[U54 HD083092] |
| WOS研究方向 | Oncology ; Pathology |
| 语种 | 英语 |
| 出版者 | E-CENTURY PUBLISHING CORP |
| WOS记录号 | WOS:000345135900007 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277258]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Hu, Ze-Lan |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 2.Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA 3.E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Kui,Liu, Ji-Wei,Zhu, Zhi-Chuan,et al. DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(10):6486-6492. |
| APA | Li, Kui.,Liu, Ji-Wei.,Zhu, Zhi-Chuan.,Wang, Hong-Tao.,Zu, Yong.,...&Hu, Ze-Lan.(2014).DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7(10),6486-6492. |
| MLA | Li, Kui,et al."DSTYK kinase domain ablation impaired the mice capabilities of learning and memory in water maze test".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7.10(2014):6486-6492. |
入库方式： OAI收割
来源：上海药物研究所
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