A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology
文献类型：期刊论文
| 作者 | Liu, Zhiguo2; Rong, Pengfei2; Gu, Xiangying3; Yu, Lun2; Chen, Guohua3; Chen, Yue-Lei4 ; Zhang, Shuai1; Shen, Jingkang4; Zeng, Wenbin2
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| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 21期号:10页码:1011-1016 |
| 关键词 | Fluorous technology glycopeptide iodination molecular probe |
| ISSN号 | 0929-8665 |
| DOI | 10.2174/0929866521666140626105814 |
| 文献子类 | Article |
| 英文摘要 | A novel and convenient strategy for iodine labeled glycopeptide molecular probe and purification was developed. The fluorine rich bi-functional coupling agent, 4-tris(2-perfluorohexylethyl)stannylbenzoate succinimidyl ester, was successfully synthesized via 5 steps starting from the fluorous Grignard reagent. It was purified by a simple and fast isolation using perfluorinated hexanes (FC-72). The "cold" iodine labeled yield for the coupling agent was as high as 92% within 15 min. The iodine-labeled product was only in organic fractions as we expected. It was shown that there was only one major peak in organic fractions according to HPLC. Finally, the iodine-labeled coupling agent was applied to label glycopeptide and afforded a high yield of 87% within 30 min. |
| WOS关键词 | SOLID-PHASE ; ORGANIC-SYNTHESIS ; RADIOPHARMACEUTICALS ; SYSTEM |
| 资助项目 | New Century Excellent Talents Project[NCET-10-0800] ; Fundamental Research Funds for the Central Universities, Hunan Provincial Natural Science Foundation of China[12JJ1012] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2012ZX09301001] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000341871000007 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277267]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zeng, Wenbin |
| 作者单位 | 1.Cent S Univ, Xiangya Hosp, Dept Otolaryngol, Changsha 410008, Hunan, Peoples R China 2.Cent S Univ, Sch Pharmaceut Sci, Changsha 410013, Hunan, Peoples R China; 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 4.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Liu, Zhiguo,Rong, Pengfei,Gu, Xiangying,et al. A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology[J]. PROTEIN AND PEPTIDE LETTERS,2014,21(10):1011-1016. |
| APA | Liu, Zhiguo.,Rong, Pengfei.,Gu, Xiangying.,Yu, Lun.,Chen, Guohua.,...&Zeng, Wenbin.(2014).A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology.PROTEIN AND PEPTIDE LETTERS,21(10),1011-1016. |
| MLA | Liu, Zhiguo,et al."A Novel Strategy for Preparing Glycopeptide Molecular Probe Using Fluorous Technology".PROTEIN AND PEPTIDE LETTERS 21.10(2014):1011-1016. |
入库方式： OAI收割
来源：上海药物研究所
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