Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease
文献类型：期刊论文
| 作者 | Wang, Peipei1,2 ; Ding, Kan2
|
| 刊名 | PROTEIN AND PEPTIDE LETTERS
 |
| 出版日期 | 2014 |
| 卷号 | 21期号:10页码:1048-1056 |
| 关键词 | Alzheimer's disease amyloid-beta protein glycosaminoglycans proteoglycans tau protein |
| ISSN号 | 0929-8665 |
| DOI | 10.2174/0929866521666140626095145 |
| 文献子类 | Article |
| 英文摘要 | Misfolded protein amyloid-beta protein (A beta) and tau protein are two high hallmarks of Alzheimer's disease (AD), representing significant targets in treating AD. Researches on mechanisms of the two proteins inducing neuron dysfunctions provide therapeutic strategies of AD, including inhibition of A beta production and aggregation, acceleration of A beta clearance as well as reduction of tau hyperphosphorylation. Proteoglycans (PGs) consist of a core protein and glycosaminoglycans (GAGs) chains, with enormous structural diversity due to variation in the core protein, the number of GAGs chains as well as extent and position of sulfation. Considerable evidences have indicated that PGs and GAGs play important roles in A beta and tau processing. Numbers of GAGs and analogues have potential therapeutic function in AD. In this Review, we focus on the relationship of PGs and GAGs with misfolded proteins in AD and their potential therapeutic implications. |
| WOS关键词 | AMYLOID PRECURSOR PROTEIN ; PAIRED HELICAL FILAMENTS ; CHONDROITIN SULFATE PROTEOGLYCANS ; BETA-SECRETASE CLEAVAGE ; CENTRAL-NERVOUS-SYSTEM ; HEPARAN-SULFATE ; A-BETA ; FIBRIL FORMATION ; TAU-PROTEIN ; NEURODEGENERATIVE DISORDERS |
| 资助项目 | National Natural Science Foundation of China (NSFC)[81171914] ; National Natural Science Foundation of China (NSFC)[31230022] ; New Drug Creation and Manufacturing Program[2012ZX09301001-003] ; National Science Fund for Distinguished Young Scholars in China[81125025] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000341871000011 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277268]  |
| 专题 | 药理学第三研究室 国家新药筛选中心 |
| 通讯作者 | Ding, Kan |
| 作者单位 | 1.Infinitus China Co Ltd, Guangzhou, Guangdong, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Glycobiol & Glycochem Lab, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Peipei,Ding, Kan. Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease[J]. PROTEIN AND PEPTIDE LETTERS,2014,21(10):1048-1056. |
| APA | Wang, Peipei,&Ding, Kan.(2014).Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease.PROTEIN AND PEPTIDE LETTERS,21(10),1048-1056. |
| MLA | Wang, Peipei,et al."Proteoglycans and Glycosaminoglycans in Misfolded Proteins Formation in Alzheimer's Disease".PROTEIN AND PEPTIDE LETTERS 21.10(2014):1048-1056. |
入库方式： OAI收割
来源：上海药物研究所
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