Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B
文献类型：期刊论文
| 作者 | Montellier, Emilie2; Boussouar, Faycal2; Rousseaux, Sophie2; Zhang, Kai4; Buchou, Thierry2; Fenaille, Francois3; Shiota, Hitoshi2; Debernardi, Alexandra2; Hery, Patrick12; Curtet, Sandrine2 |
| 刊名 | GENES & DEVELOPMENT
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 27期号:15页码:1680-1692 |
| 关键词 | H2AZ BRDT male contraception reprogramming male infertility sex chromosome inactivation histone eviction |
| ISSN号 | 0890-9369 |
| DOI | 10.1101/gad.220095.113 |
| 文献子类 | Article |
| 英文摘要 | The conversion of male germ cell chromatin to a nucleoprotamine structure is fundamental to the life cycle, yet the underlying molecular details remain obscure. Here we show that an essential step is the genome-wide incorporation of TH2B, a histone H2B variant of hitherto unknown function. Using mouse models in which TH2B is depleted or C-terminally modified, we show that TH2B directs the final transformation of dissociating nucleosomes into protamine-packed structures. Depletion of TH2B induces compensatory mechanisms that permit histone removal by up-regulating H2B and programming nucleosome instability through targeted histone modifications, including lysine crotonylation and arginine methylation. Furthermore, after fertilization, TH2B reassembles onto the male genome during protamine-to-histone exchange. Thus, TH2B is a unique histone variant that plays a key role in the histone-to-protamine packing of the male genome and guides genome-wide chromatin transitions that both precede and follow transmission of the male genome to the egg. |
| WOS关键词 | RAT TESTIS ; ACETYLATION ; HETEROCHROMATIN ; TRANSCRIPTION ; BROMODOMAIN ; MARKS ; SPERMIOGENESIS ; IDENTIFICATION ; CROTONYLATION ; NUCLEOSOMES |
| 资助项目 | ANR EpiSperm2 grant[00000000] ; INCa[00000000] ; "ARC libre'' funds[00000000] ; MTR bourse flechee[00000000] ; ARC fellowship[00000000] ; European Commission[00000000] ; "contrat jeune chercheur'' INSERM[00000000] ; IBiSA, Aix-Marseille Universite[00000000] ; [ANR-10-INBS-0009-10] |
| WOS研究方向 | Cell Biology ; Developmental Biology ; Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000322716000006 |
| 出版者 | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277521]  |
| 专题 | 化学蛋白质组学研究中心 |
| 通讯作者 | Khochbin, Saadi |
| 作者单位 | 1.CHU Angers, F-49000 Angers, France; 2.Univ Grenoble 1, Inst Albert Bonniot, INSERM, U823, F-38700 Grenoble, France; 3.Commissariat Energie Atom & Energies Alternat CEA, Lab Etud Metab Med, Direct Sci Vivant, Inst Biol & Technol Saclay iBiTec S,Inst Biol Tec, F-91191 Gif Sur Yvette, France; 4.Nankai Univ, Dept Chem, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 6.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA; 7.Univ Grenoble Alpes, CNRS, CEA, Inst Biol Struct, F-38027 Grenoble, France; 8.Univ Grenoble 1, Grenoble Inst Neurosci, INSERM, U836, F-38700 Grenoble, France; 9.Univ Angers, UMR S 892, Ctr Rech Canc Nantes Angers, U892,INSERM,Plateforme SNP, F-49000 Angers, France; 10.Aix Marseille Univ, TGML TAGC, Marseille, France; |
| 推荐引用方式 GB/T 7714 | Montellier, Emilie,Boussouar, Faycal,Rousseaux, Sophie,et al. Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B[J]. GENES & DEVELOPMENT,2013,27(15):1680-1692. |
| APA | Montellier, Emilie.,Boussouar, Faycal.,Rousseaux, Sophie.,Zhang, Kai.,Buchou, Thierry.,...&Khochbin, Saadi.(2013).Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B.GENES & DEVELOPMENT,27(15),1680-1692. |
| MLA | Montellier, Emilie,et al."Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B".GENES & DEVELOPMENT 27.15(2013):1680-1692. |
入库方式： OAI收割
来源：上海药物研究所
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