Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction
文献类型：期刊论文
| 作者 | Liu, Wen-Jing1; Mei, De-Sheng2; Duan, Wen-Hu1,2
|
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2013-06 |
| 卷号 | 24期号:6页码:515-517 |
| 关键词 | 1,7-Dimethoxy-2-hydroxyxanthone Erectile dysfunction Synthesis Copper-catalyzed coupling reaction |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2013.03.038 |
| 文献子类 | Article |
| 英文摘要 | The natural product, 1,7-dimethoxy-2-hydroxyxanthone (1), isolated from Securidaca inappendiculate Hassk, has a potential in the treatment of erectile dysfunction due to its significant relaxation activity on rabbit Corpus cavernosum. However, the isolation of compound 1 is problematic because of its high similarity in structure to its analogs. In this paper, the first synthesis of 1 was reported featuring two key reactions: a copper-catalyzed coupling reaction and an intramolecular cyclization. (C) 2013 De-Sheng Mei, Wen-Hu Duan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| WOS关键词 | SECURIDACA-INAPPENDICULATA ; XANTHONES ; DERIVATIVES ; CYCLIZATION ; MOLECULES ; ANALOGS ; ACID ; RING |
| 资助项目 | National Natural Science Foundation[81102461] ; National Natural Science Foundation[81021062] ; National Natural Science Foundation[90813034] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09301001-001] ; National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"[2012ZX09103101-024] ; Shanghai Science and Technology Commission[11431921100] ; Shanghai Science and Technology Commission[12DZ1930802] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000320901400022 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277592]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Mei, De-Sheng |
| 作者单位 | 1.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Wen-Jing,Mei, De-Sheng,Duan, Wen-Hu. Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction[J]. CHINESE CHEMICAL LETTERS,2013,24(6):515-517. |
| APA | Liu, Wen-Jing,Mei, De-Sheng,&Duan, Wen-Hu.(2013).Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction.CHINESE CHEMICAL LETTERS,24(6),515-517. |
| MLA | Liu, Wen-Jing,et al."Synthesis of 1,7-dimethoxy-2-hydroxyxanthone, a natural product with potential activity on erectile dysfunction".CHINESE CHEMICAL LETTERS 24.6(2013):515-517. |
入库方式： OAI收割
来源：上海药物研究所
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