Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity
文献类型：期刊论文
| 作者 | Wu, Meng1; Wang, Zi-Wen1; Liu, Yu-Xiu1; Song, Hai-Bin1; Zhang, Ao2 ; Meng, Ling-Hua2; Wang, Qing-Min1
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| 刊名 | NEW JOURNAL OF CHEMISTRY
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| 出版日期 | 2013 |
| 卷号 | 37期号:6页码:1817-1822 |
| ISSN号 | 1144-0546 |
| DOI | 10.1039/c3nj00031a |
| 文献子类 | Article |
| 英文摘要 | Salification is most commonly employed for modifying physical and chemical properties. However, there are few reports on the differences in biological activity between different salt forms and free alkaloids. The salt derivatives of tylophorine and (S)-6-O-desmethylantofine were prepared and systematically evaluated for their antitumor activities against A-549 and HL-60 cell lines. Our bioassay results revealed that different salt derivatives exhibited quite different antitumor activity but the activity did not have a distinct relationship with the strength of the acid or the bonding mode of the alkaloid with the acid. Some of the salt derivatives showed very high in vitro antitumor activity, of which (S)-6-O-desmethylantofine hydroiodide with a low nanomolar level of antitumor activity (GI(50): 10 nM for A-549 and HL-60 cell lines) emerged as a new lead for further development as a novel antitumor agent. |
| WOS关键词 | PHENANTHROQUINOLIZIDINE ALKALOIDS ; TYLOPHORINE ANALOG ; CYTOTOXIC ACTIVITY ; CELL-GROWTH ; CYNANCHUM-VINCETOXICUM ; BIOLOGICAL-ACTIVITY ; ANTICANCER AGENTS ; ANTOFINE ANALOGS ; FICUS-SEPTICA ; CANCER-CELLS |
| 资助项目 | National Key Project for Basic Research[2010CB126106] ; National Key Technology Research and Development Program[2011BAE06B05] ; Tianjin Natural Science Foundation[11JCZDJC20500] ; China Postdoctoral Science Foundation[2011M500519] ; China Postdoctoral Science Foundation[2012T50207] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000319127900026 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277793]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.Nankai Univ, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Meng,Wang, Zi-Wen,Liu, Yu-Xiu,et al. Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity[J]. NEW JOURNAL OF CHEMISTRY,2013,37(6):1817-1822. |
| APA | Wu, Meng.,Wang, Zi-Wen.,Liu, Yu-Xiu.,Song, Hai-Bin.,Zhang, Ao.,...&Wang, Qing-Min.(2013).Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity.NEW JOURNAL OF CHEMISTRY,37(6),1817-1822. |
| MLA | Wu, Meng,et al."Different salt derivatives of phenanthroindolizidine alkaloids display different in vitro antitumor activity".NEW JOURNAL OF CHEMISTRY 37.6(2013):1817-1822. |
入库方式： OAI收割
来源：上海药物研究所
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