Synthesis Study toward Mayamycin
文献类型：期刊论文
| 作者 | Wu, Kui2; Wang, Meining1; Yao, Qizheng2; Zhang, Ao1
|
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2013-01 |
| 卷号 | 31期号:1页码:93-99 |
| 关键词 | natural product angucycline mayamycin total synthesis C-glycosilation |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.201201084 |
| 文献子类 | Article |
| 英文摘要 | Natural product mayamycin is the first example in the angucycline class featuring a C-glycoside linkage at the C5-position of the benz[a]anthracenone core with remarkable biological activities. We successfully synthesized the two retrosynthetic fragments, but found that the final C-glycosylation did not occur. Alternatively, an A-ring saturated aglycon was prepared, but the proposed C-glycosylation still did not proceed. Finally, a simplified substrate was used and the subsequent C-glycosylation went through smoothly, giving a two-ring less analogue of mayamycin. |
| WOS关键词 | C-ARYL GLYCOSIDES ; ANGUCYCLINE ANTIBIOTICS ; MM-47755 ; (-)-TETRANGOMYCIN ; TETRANGULOL ; SUGAR |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4751398 |
| WOS记录号 | WOS:000313811800019 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277814]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yao, Qizheng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Synthet Organ & Med Chem Lab, Shanghai 201203, Peoples R China 2.China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wu, Kui,Wang, Meining,Yao, Qizheng,et al. Synthesis Study toward Mayamycin[J]. CHINESE JOURNAL OF CHEMISTRY,2013,31(1):93-99. |
| APA | Wu, Kui,Wang, Meining,Yao, Qizheng,&Zhang, Ao.(2013).Synthesis Study toward Mayamycin.CHINESE JOURNAL OF CHEMISTRY,31(1),93-99. |
| MLA | Wu, Kui,et al."Synthesis Study toward Mayamycin".CHINESE JOURNAL OF CHEMISTRY 31.1(2013):93-99. |
入库方式： OAI收割
来源：上海药物研究所
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