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Rhodium-Catalyzed Oxidative ortho-Acylation of Aryl Ketone O-Methyl Oximes with Aryl and Alkyl Aldehydes

文献类型：期刊论文

作者Yang, Yaxi; Zhou, Bing; Li, Yuanchao
刊名ADVANCED SYNTHESIS & CATALYSIS
出版日期2012-11
卷号354期号:16页码:2916-2920
关键词acylation aldehydes aryl ketone O-methyl oximes C-H activation rhodium catalysis
ISSN号1615-4150
DOI10.1002/adsc.201200401
文献子类Article
英文摘要The rhodium-catalyzed oxidative ortho-acylation of aryl ketone O-methyl oximes with aryl and alkyl aldehydes via C?H bond activation is described. The cross-coupling reaction exhibits high functional group tolerance and regioselectivity under relatively mild conditions and constitutes a versatile route to a diverse library of diaryl ketones, which are difficult to obtain by the classical FriedelCrafts acylation. Moreover, this reaction proceeds via an unprecedented Rh-catalyzed oxidative ortho-acylation of aryl ketone O-methyl oximes with highly electron-deficient aryl aldehydes followed by a direct addition of the second ortho C-H bond to aldehydes in a one-pot reaction, to generate two C-C bonds simultaneously.
WOS关键词C-H BOND ; TERT-BUTYL HYDROPEROXIDE ; DIRECT FUNCTIONALIZATION ; ORGANIC-SYNTHESIS ; ACTIVATION ; BENZAMIDES ; NITRILES ; ACETANILIDES ; INSERTION ; REAGENTS
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000310879100004
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/277880]  
专题药物化学研究室
通讯作者Zhou, Bing
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yaxi,Zhou, Bing,Li, Yuanchao. Rhodium-Catalyzed Oxidative ortho-Acylation of Aryl Ketone O-Methyl Oximes with Aryl and Alkyl Aldehydes[J]. ADVANCED SYNTHESIS & CATALYSIS,2012,354(16):2916-2920.
APA Yang, Yaxi,Zhou, Bing,&Li, Yuanchao.(2012).Rhodium-Catalyzed Oxidative ortho-Acylation of Aryl Ketone O-Methyl Oximes with Aryl and Alkyl Aldehydes.ADVANCED SYNTHESIS & CATALYSIS,354(16),2916-2920.
MLA Yang, Yaxi,et al."Rhodium-Catalyzed Oxidative ortho-Acylation of Aryl Ketone O-Methyl Oximes with Aryl and Alkyl Aldehydes".ADVANCED SYNTHESIS & CATALYSIS 354.16(2012):2916-2920.

入库方式： OAI收割

来源：上海药物研究所

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