Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina
文献类型：期刊论文
| 作者 | Yu, Qianming2,3; Yan, Jun2,3; Wang, Shunchun2,3; Ji, Lili2,3; Ding, Kan1 ; Vella, Cherelyn4; Wang, Zhengtao2,3; Hu, Zhibi2,3
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| 刊名 | GLYCOBIOLOGY
 |
| 出版日期 | 2012-10 |
| 卷号 | 22期号:10页码:1343-1352 |
| 关键词 | antiangiogenesis Grateloupia filicina HUVEC sulfated agaran tissue factor |
| ISSN号 | 0959-6658 |
| DOI | 10.1093/glycob/cws096 |
| 文献子类 | Article |
| 英文摘要 | An agaran-type polysaccharide, GFP08, isolated from Grateloupia filicina (C. Agardh) Lamouroux, was mainly composed of 1,3-linked beta-d-galactose partially sulfated at position O-2 and 1,4-linked alpha-l-galactose O-2, O-3-disulfate, alpha-l-galactose O-6-sulfate and 3,6-anhydro-alpha-l-galactose. Small quantities of xylose, 4,6-O-(1'-carboxyethylidene) and 6-O-methyl-beta-d-galactose were also present. In mice bearing sarcoma-180 cells, GFP08 decreased tumor weight in a dose-dependent manner. The antiangiogenic activity of GFP08 was evaluated using the chicken chorioallantoic membrane assay, and the results showed that GFP08 dose-dependently reduced new vessel formation. Meanwhile, GFP08 inhibited the differentiation of human umbilical vein endothelial cells (HUVECs) into capillary-like structures in vitro and reduced the number of migrated cells. However, there was no observed cytotoxicity of GFP08 toward HUVECs. Further study revealed that GFP08 decreased tissue factor (TF) expression without affecting the activities of matrix metalloproteinase-2 and -9. All those data indicated that GFP08 had an antitumor effect that might be associated in part with its antiangiogenic effect through down-regulating the expression of TF protein. |
| WOS关键词 | C-13 NMR-SPECTROSCOPY ; RED ALGAL GALACTANS ; SULFATED GALACTAN ; TISSUE FACTOR ; MATRIX METALLOPROTEINASES ; STRUCTURAL FEATURES ; DIMETHYL-SULFOXIDE ; ANGIOGENIC SWITCH ; RHODOPHYTA ; CANCER |
| 资助项目 | "Shanghai Rising-Star" Program[09QH1402200] ; Program for New Century Excellent Talents in University[NECT-10-0886] ; Shanghai Education Commission[08SG44] |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000308011800007 |
| 出版者 | OXFORD UNIV PRESS INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277935]  |
| 专题 | 药理学第三研究室 |
| 通讯作者 | Wang, Shunchun |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shanghai Univ Tradit Chinese Med, MOE Key Lab Standardizat Chinese Med, Inst Chinese Mat Med, Shanghai 201210, Peoples R China; 3.Shanghai Univ Tradit Chinese Med, SATCM Key Lab New Resources & Qual Evaluat Chines, Inst Chinese Mat Med, Shanghai 201210, Peoples R China; 4.London Metropolitan Univ, Inst Hlth Res & Policy, London N7 8DB, England |
| 推荐引用方式 GB/T 7714 | Yu, Qianming,Yan, Jun,Wang, Shunchun,et al. Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina[J]. GLYCOBIOLOGY,2012,22(10):1343-1352. |
| APA | Yu, Qianming.,Yan, Jun.,Wang, Shunchun.,Ji, Lili.,Ding, Kan.,...&Hu, Zhibi.(2012).Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina.GLYCOBIOLOGY,22(10),1343-1352. |
| MLA | Yu, Qianming,et al."Antiangiogenic effects of GFP08, an agaran-type polysaccharide isolated from Grateloupia filicina".GLYCOBIOLOGY 22.10(2012):1343-1352. |
入库方式： OAI收割
来源：上海药物研究所
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