A diastereoselective synthesis of 7 alpha-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone
文献类型：期刊论文
| 作者 | Zhang, Bin; Chen, Hongli; Tang, Huanyu; Feng, Huijin ; Li, Yuanchao
|
| 刊名 | STEROIDS
 |
| 出版日期 | 2012-09 |
| 卷号 | 77期号:11页码:1086-1091 |
| 关键词 | Nitromethane Eplerenone 1,6-Conjugated addition Quaternary ammonium salt Synthesis |
| ISSN号 | 0039-128X |
| DOI | 10.1016/j.steroids.2012.04.017 |
| 文献子类 | Article |
| 英文摘要 | A novel and efficient method of stereoselectively introducing alpha-nitromethyl group to C-7 position of 11 alpha-hydroxyl canrenone 4 was described. In addition, this method was successfully applied in a total synthesis of Eplerenone 8. The route was characteristic of simple operation, moderate reaction conditions with 5 steps and 55% total yield, at the same time, without any expensive or toxic reagent in use. (C) 2012 Elsevier Inc. All rights reserved. |
| WOS关键词 | HENRY REACTION |
| 资助项目 | National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program", China[2009ZX09102-026] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Endocrinology & Metabolism |
| 语种 | 英语 |
| WOS记录号 | WOS:000309021700008 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/277956]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Bin,Chen, Hongli,Tang, Huanyu,et al. A diastereoselective synthesis of 7 alpha-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone[J]. STEROIDS,2012,77(11):1086-1091. |
| APA | Zhang, Bin,Chen, Hongli,Tang, Huanyu,Feng, Huijin,&Li, Yuanchao.(2012).A diastereoselective synthesis of 7 alpha-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone.STEROIDS,77(11),1086-1091. |
| MLA | Zhang, Bin,et al."A diastereoselective synthesis of 7 alpha-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone".STEROIDS 77.11(2012):1086-1091. |
入库方式： OAI收割
来源：上海药物研究所
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