中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors

文献类型:期刊论文

作者Huang Shaoxu; Wang Yong; Long Yaqiu
刊名CHINESE JOURNAL OF ORGANIC CHEMISTRY
出版日期2012-05
卷号32期号:5页码:877-888
关键词soluble epoxide hydrolase epoxyeicosatrienoic acid inhibitors 1,3-disubstituted urea hypertension inflammation
ISSN号0253-2786
DOI10.6023/cjoc1107132
文献子类Review
英文摘要Hypertension is a common illness nowadays. Although a wide variety of antihypertensive agents are available in the market for the treatment of hypertension, the antihypertensive treatment tends to be individualized, and the treatment should exceed the limitation of lowering blood pressure only. Compared to other antihypertensive agents, the advantage of human soluble epoxide hydrolase inhibitors (HsEHIs) is that they can not only reduce the blood pressure, but also have remarkable anti-inflammatory effects. Herein, the development of human soluble epoxide hydrolase inhibitors is reviewed from early epoxide HsEHIs to the third generation of urea HsEHIs.
WOS关键词UREA-BASED INHIBITORS ; BLOOD-PRESSURE ; EPOXYEICOSATRIENOIC ACIDS ; WATER SOLUBILITY ; HIGHLY POTENT ; ARENE OXIDES ; HYPERTENSION ; HYDROLYSIS ; MECHANISM ; DISCOVERY
资助项目National Natural Science Foundation of China[81021062] ; National Natural Science Foundation of China[81072527]
WOS研究方向Chemistry
语种中文
CSCD记录号CSCD:4539058
WOS记录号WOS:000304841300007
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/278086]  
专题药物化学研究室
通讯作者Huang Shaoxu
作者单位Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Lab Med Chem, Shanghai 201203, Peoples R China
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Huang Shaoxu,Wang Yong,Long Yaqiu. Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(5):877-888.
APA Huang Shaoxu,Wang Yong,&Long Yaqiu.(2012).Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(5),877-888.
MLA Huang Shaoxu,et al."Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.5(2012):877-888.

入库方式: OAI收割

来源:上海药物研究所

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