Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors
文献类型：期刊论文
| 作者 | Huang Shaoxu; Wang Yong; Long Yaqiu |
| 刊名 | CHINESE JOURNAL OF ORGANIC CHEMISTRY
 |
| 出版日期 | 2012-05 |
| 卷号 | 32期号:5页码:877-888 |
| 关键词 | soluble epoxide hydrolase epoxyeicosatrienoic acid inhibitors 1,3-disubstituted urea hypertension inflammation |
| ISSN号 | 0253-2786 |
| DOI | 10.6023/cjoc1107132 |
| 文献子类 | Review |
| 英文摘要 | Hypertension is a common illness nowadays. Although a wide variety of antihypertensive agents are available in the market for the treatment of hypertension, the antihypertensive treatment tends to be individualized, and the treatment should exceed the limitation of lowering blood pressure only. Compared to other antihypertensive agents, the advantage of human soluble epoxide hydrolase inhibitors (HsEHIs) is that they can not only reduce the blood pressure, but also have remarkable anti-inflammatory effects. Herein, the development of human soluble epoxide hydrolase inhibitors is reviewed from early epoxide HsEHIs to the third generation of urea HsEHIs. |
| WOS关键词 | UREA-BASED INHIBITORS ; BLOOD-PRESSURE ; EPOXYEICOSATRIENOIC ACIDS ; WATER SOLUBILITY ; HIGHLY POTENT ; ARENE OXIDES ; HYPERTENSION ; HYDROLYSIS ; MECHANISM ; DISCOVERY |
| 资助项目 | National Natural Science Foundation of China[81021062] ; National Natural Science Foundation of China[81072527] |
| WOS研究方向 | Chemistry |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4539058 |
| WOS记录号 | WOS:000304841300007 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278086]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Huang Shaoxu |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Lab Med Chem, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Huang Shaoxu,Wang Yong,Long Yaqiu. Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY,2012,32(5):877-888. |
| APA | Huang Shaoxu,Wang Yong,&Long Yaqiu.(2012).Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors.CHINESE JOURNAL OF ORGANIC CHEMISTRY,32(5),877-888. |
| MLA | Huang Shaoxu,et al."Advances in the Research of Human Soluble Epoxide Hydrolase Inhibitors".CHINESE JOURNAL OF ORGANIC CHEMISTRY 32.5(2012):877-888. |
入库方式： OAI收割
来源：上海药物研究所
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