中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines

文献类型:期刊论文

作者Fei, Xiang-Dong1; Zhou, Zhou1; Li, Wen1; Zhu, Yong-Ming1; Shen, Jing-Kang2
刊名EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
出版日期2012-05
期号15页码:3001-3008
关键词Palladium Cyclization Michael addition Dehydrogenation Hetero-cycles
ISSN号1434-193X
DOI10.1002/ejoc.201200172
文献子类Article
英文摘要The BuchwaldHartwig coupling/Michael addition sequence has been successfully applied to the synthesis of functionalized 1,2-disubstituted 4-quinolones using Pd(OAc)2 as a catalyst and PPh3 as a ligand. Under these conditions, the intermediate products first formed from chalcones and primary amines underwent catalytic dehydrogenation to yield the 1,2-disubstituted 4-quinolones.
WOS关键词HIV-1 INTEGRASE INHIBITORS ; ANTIBACTERIAL ACTIVITY ; CATALYZED AMIDATION ; ANTIMITOTIC AGENTS ; DERIVATIVES ; CYCLIZATION ; 2-ARYL-4-QUINOLONES ; QUINOLONES ; ROUTE ; ACIDS
资助项目Jiangsu Higher Education Institutions[00000000] ; National Nature Science Foundation of China (NSFC)[81172954]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000303994100013
出版者WILEY-V C H VERLAG GMBH
源URL[http://119.78.100.183/handle/2S10ELR8/278091]  
专题药物化学研究室
通讯作者Zhu, Yong-Ming
作者单位1.Soochow Univ, Sch Pharm, Suzhou 215123, Peoples R China;
2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Fei, Xiang-Dong,Zhou, Zhou,Li, Wen,et al. Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(15):3001-3008.
APA Fei, Xiang-Dong,Zhou, Zhou,Li, Wen,Zhu, Yong-Ming,&Shen, Jing-Kang.(2012).Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(15),3001-3008.
MLA Fei, Xiang-Dong,et al."Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .15(2012):3001-3008.

入库方式: OAI收割

来源:上海药物研究所

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