Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines
文献类型:期刊论文
作者 | Fei, Xiang-Dong1; Zhou, Zhou1; Li, Wen1; Zhu, Yong-Ming1; Shen, Jing-Kang2 |
刊名 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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出版日期 | 2012-05 |
期号 | 15页码:3001-3008 |
关键词 | Palladium Cyclization Michael addition Dehydrogenation Hetero-cycles |
ISSN号 | 1434-193X |
DOI | 10.1002/ejoc.201200172 |
文献子类 | Article |
英文摘要 | The BuchwaldHartwig coupling/Michael addition sequence has been successfully applied to the synthesis of functionalized 1,2-disubstituted 4-quinolones using Pd(OAc)2 as a catalyst and PPh3 as a ligand. Under these conditions, the intermediate products first formed from chalcones and primary amines underwent catalytic dehydrogenation to yield the 1,2-disubstituted 4-quinolones. |
WOS关键词 | HIV-1 INTEGRASE INHIBITORS ; ANTIBACTERIAL ACTIVITY ; CATALYZED AMIDATION ; ANTIMITOTIC AGENTS ; DERIVATIVES ; CYCLIZATION ; 2-ARYL-4-QUINOLONES ; QUINOLONES ; ROUTE ; ACIDS |
资助项目 | Jiangsu Higher Education Institutions[00000000] ; National Nature Science Foundation of China (NSFC)[81172954] |
WOS研究方向 | Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000303994100013 |
出版者 | WILEY-V C H VERLAG GMBH |
源URL | [http://119.78.100.183/handle/2S10ELR8/278091] ![]() |
专题 | 药物化学研究室 |
通讯作者 | Zhu, Yong-Ming |
作者单位 | 1.Soochow Univ, Sch Pharm, Suzhou 215123, Peoples R China; 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | Fei, Xiang-Dong,Zhou, Zhou,Li, Wen,et al. Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY,2012(15):3001-3008. |
APA | Fei, Xiang-Dong,Zhou, Zhou,Li, Wen,Zhu, Yong-Ming,&Shen, Jing-Kang.(2012).Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines.EUROPEAN JOURNAL OF ORGANIC CHEMISTRY(15),3001-3008. |
MLA | Fei, Xiang-Dong,et al."Buchwald-Hartwig Coupling/Michael Addition Reactions: One-Pot Synthesis of 1,2-Disubstituted 4-Quinolones from Chalcones and Primary Amines".EUROPEAN JOURNAL OF ORGANIC CHEMISTRY .15(2012):3001-3008. |
入库方式: OAI收割
来源:上海药物研究所
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