A Concise Synthetic Approach to (+)-Valienamine Starting from Garner's Aldehyde
文献类型：期刊论文
| 作者 | Zhou, Bing2 ; Luo, Zhi2; Lin, Sui1; Li, Yuanchao2
|
| 刊名 | SYNLETT
 |
| 出版日期 | 2012-04 |
| 期号 | 6页码:913-916 |
| 关键词 | (+)-valienamine Garner's aldehyde diastereoselective hydrozirconation-transmetalation intramolecular aldol reaction |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-0031-1290614 |
| 文献子类 | Article |
| 英文摘要 | A synthesis of (+)-valienamine was achieved starting from Garner's aldehyde in ten steps and 23% overall yield. A unique feature of the synthetic route is that an acyclic precursor was constructed, using diastereoselective antireductive coupling reaction of alkyne and Garner's aldehyde as the key step, which was then cyclized in an intramolecular aldol reaction to form the valienamine skeleton. |
| WOS关键词 | D-ERYTHRO-SPHINGOSINE ; ALPHA-GLUCOSIDASE INHIBITORS ; D-THREO-SPHINGOSINE ; FLAVOBACTERIUM-SACCHAROPHILUM ; ENANTIOSPECIFIC SYNTHESES ; STEREODIVERGENT SYNTHESIS ; ASYMMETRIC INDUCTION ; EFFICIENT SYNTHESIS ; N-BROMOSUCCINIMIDE ; ALLYLIC ALCOHOLS |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', P. R. of China[2009ZX09102-026] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000302119600021 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278139]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | 1.Fujian Inst Med Sci, Fuzhou 350001, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhou, Bing,Luo, Zhi,Lin, Sui,et al. A Concise Synthetic Approach to (+)-Valienamine Starting from Garner's Aldehyde[J]. SYNLETT,2012(6):913-916. |
| APA | Zhou, Bing,Luo, Zhi,Lin, Sui,&Li, Yuanchao.(2012).A Concise Synthetic Approach to (+)-Valienamine Starting from Garner's Aldehyde.SYNLETT(6),913-916. |
| MLA | Zhou, Bing,et al."A Concise Synthetic Approach to (+)-Valienamine Starting from Garner's Aldehyde".SYNLETT .6(2012):913-916. |
入库方式： OAI收割
来源：上海药物研究所
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