Histone crotonylation specifically marks the haploid male germ cell gene expression program
文献类型：期刊论文
| 作者 | Montellier, Emilie3; Rousseaux, Sophie3; Zhao, Yingming1,2 ; Khochbin, Saadi3
|
| 刊名 | BIOESSAYS
 |
| 出版日期 | 2012-03 |
| 卷号 | 34期号:3页码:187-193 |
| ISSN号 | 0265-9247 |
| 关键词 | acetylation H2A X H2A Z histone variants macroH2A |
| DOI | 10.1002/bies.201100141 |
| 文献子类 | Article |
| 英文摘要 | The haploid male germ cell differentiation program controls essential steps of male gametogenesis and relies partly on a significant number of sex chromosome-linked genes. These genes need to escape chromosome-wide transcriptional repression of sex chromosomes, which occurs during meiosis and is largely maintained in post-meiotic cells. A newly discovered histone lysine modification, crotonylation (Kcr), marks X/Y-linked genes that are active in post-meiotic male germ cells. Histone Kcr, by conferring resistance to transcriptional repressors, could be a dominant element in maintaining these genes active in the globally repressive environment of haploid cell sex chromosomes. Furthermore, the same mark was found associated with post-meiotically activated genes on autosomes. Histone Kcr therefore appears to be an indicator of the male haploid cell gene expression program and a notable element of genome programming in the post-meiotic phases of spermatogenesis. |
| WOS关键词 | SEX-CHROMOSOME INACTIVATION ; MOUSE X-CHROMOSOME ; NUCLEAR COMPARTMENTALIZATION ; MALE GENOME ; CHROMATIN ; MEIOSIS ; SPERMATOGENESIS ; BROMODOMAIN ; SPERMATIDS ; MICE |
| 资助项目 | ANR[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| 出版者 | WILEY-BLACKWELL |
| WOS记录号 | WOS:000300448900009 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278171]  |
| 专题 | 化学蛋白质组学研究中心 |
| 通讯作者 | Khochbin, Saadi |
| 作者单位 | 1.Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 200031, Peoples R China; 3.Univ Grenoble 1, INSERM, Inst Albert Bonniot, Fac Med,U823, La Tronche, France; |
| 推荐引用方式 GB/T 7714 | Montellier, Emilie,Rousseaux, Sophie,Zhao, Yingming,et al. Histone crotonylation specifically marks the haploid male germ cell gene expression program[J]. BIOESSAYS,2012,34(3):187-193. |
| APA | Montellier, Emilie,Rousseaux, Sophie,Zhao, Yingming,&Khochbin, Saadi.(2012).Histone crotonylation specifically marks the haploid male germ cell gene expression program.BIOESSAYS,34(3),187-193. |
| MLA | Montellier, Emilie,et al."Histone crotonylation specifically marks the haploid male germ cell gene expression program".BIOESSAYS 34.3(2012):187-193. |
入库方式： OAI收割
来源：上海药物研究所
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