Synthesis of Entecavir (BMS-200475)
文献类型：期刊论文
| 作者 | Zhou, Bing ; Li, Yuanchao
|
| 刊名 | TETRAHEDRON LETTERS
 |
| 出版日期 | 2012-02-01 |
| 卷号 | 53期号:5页码:502-504 |
| 关键词 | Entecavir BMS-200475 Highly diastereoselective Intramolecular nitrile oxide cycloaddition Hepatitis B virus |
| ISSN号 | 0040-4039 |
| DOI | 10.1016/j.tetlet.2011.11.073 |
| 文献子类 | Article |
| 英文摘要 | A synthesis of Entecavir (BMS-200475) was achieved starting from 1,3-propanediol in 15 steps and 23.4% overall yield. A unique feature of the synthetic route is that the five-membered carbocyclic core is installed by an intramolecular nitrile oxide cycloaddition (INOC) reaction and the guanine moiety is introduced by a Mitsunobu reaction. The route is characteristic of low cost, high yield and easy operation. (C) 2011 Elsevier Ltd. All rights reserved. |
| WOS关键词 | HEPATITIS-B VIRUS ; OXIDATION ; POTENT |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09102-026] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000300029000008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278203]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bing,Li, Yuanchao. Synthesis of Entecavir (BMS-200475)[J]. TETRAHEDRON LETTERS,2012,53(5):502-504. |
| APA | Zhou, Bing,&Li, Yuanchao.(2012).Synthesis of Entecavir (BMS-200475).TETRAHEDRON LETTERS,53(5),502-504. |
| MLA | Zhou, Bing,et al."Synthesis of Entecavir (BMS-200475)".TETRAHEDRON LETTERS 53.5(2012):502-504. |
入库方式： OAI收割
来源：上海药物研究所
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