Rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to heteroaryl alpha-ketoesters for synthesis of heteroaromatic alpha-hydroxy esters
文献类型：期刊论文
| 作者 | Wang, Hui; Zhu, Ting-Shun; Xu, Ming-Hua
|
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2012 |
| 卷号 | 10期号:46页码:9158-9164 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c2ob26316e |
| 文献子类 | Article |
| 英文摘要 | The first example of catalytic asymmetric 1,2-addition of arylboronic acids to heteroaryl alpha-ketoesters has been developed for the highly efficient and enantioselective synthesis of quaternary carbon-containing heteroaromatic alpha-hydroxy esters. The reaction works well with a variety of alpha-ketoesters including 3-indoleglyoxylates, 3-benzofuranglyoxylates and 3-benzothiopheneglyoxylates under very mild conditions, affording the corresponding products in moderate to good yields with high enantiomeric excesses (up to 97%). |
| WOS关键词 | FRIEDEL-CRAFTS ALKYLATION ; SULFUR-OLEFIN LIGANDS ; ARYL BORONIC ACIDS ; ASYMMETRIC ADDITION ; ETHYL TRIFLUOROPYRUVATE ; ALPHA,BETA-UNSATURATED KETONES ; INDOLE ALKALOIDS ; ALDEHYDES ; PALLADACYCLES ; 1,4-ADDITION |
| 资助项目 | National Natural Science Foundation of China[20972172] ; National Natural Science Foundation of China[21021063] ; Chinese Academy of Sciences[00000000] ; SIMM[00000000] ; National Science & Technology Major Project[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000310809800008 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278236]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Hui,Zhu, Ting-Shun,Xu, Ming-Hua. Rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to heteroaryl alpha-ketoesters for synthesis of heteroaromatic alpha-hydroxy esters[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2012,10(46):9158-9164. |
| APA | Wang, Hui,Zhu, Ting-Shun,&Xu, Ming-Hua.(2012).Rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to heteroaryl alpha-ketoesters for synthesis of heteroaromatic alpha-hydroxy esters.ORGANIC & BIOMOLECULAR CHEMISTRY,10(46),9158-9164. |
| MLA | Wang, Hui,et al."Rhodium-catalyzed enantioselective 1,2-addition of arylboronic acids to heteroaryl alpha-ketoesters for synthesis of heteroaromatic alpha-hydroxy esters".ORGANIC & BIOMOLECULAR CHEMISTRY 10.46(2012):9158-9164. |
入库方式： OAI收割
来源：上海药物研究所
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