Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain
文献类型：期刊论文
| 作者 | Fu, Li Qiang; Ling, Chen Yu; Guo, Xing Sheng; He, Hui Li; Yang, Yu She |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2012-01 |
| 卷号 | 23期号:1页码:9-12 |
| 关键词 | Synthesis Pleuromutilin Novel side chains Antibacterial activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2011.10.002 |
| 文献子类 | Article |
| 英文摘要 | In order to find novel antibacterial agents with superior antibacterial activity and overcoming multidrug resistance, a series of pleuromutilin derivatives with novel C(14) side chain were synthesized and evaluated for their in vitro antibacterial activities. The results of antibacterial acticities indicated that most of the derivatives showed potent activities against Gram-positive organisms. In particular, compound 10d exhibited the most potent inhibitory activity compared with pleuromutilin and linezoid, emerged as potential molecule for further investigation. (C) 2011 Yu She Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
| WOS关键词 | GRAM-POSITIVE PATHOGENS ; IN-VITRO ; PART 1 ; INHIBITORS ; BINDING |
| 资助项目 | National Science and Technology Major Project[00000000] ; Key New Drug Creation and Manufacturing Program, China[2009ZX09301-001] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| CSCD记录号 | CSCD:4434131 |
| WOS记录号 | WOS:000299364300003 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278281]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yang, Yu She |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Li Qiang,Ling, Chen Yu,Guo, Xing Sheng,et al. Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain[J]. CHINESE CHEMICAL LETTERS,2012,23(1):9-12. |
| APA | Fu, Li Qiang,Ling, Chen Yu,Guo, Xing Sheng,He, Hui Li,&Yang, Yu She.(2012).Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain.CHINESE CHEMICAL LETTERS,23(1),9-12. |
| MLA | Fu, Li Qiang,et al."Synthesis and antibacterial activity of pleuromutilin derivatives with novel C(14) side chain".CHINESE CHEMICAL LETTERS 23.1(2012):9-12. |
入库方式： OAI收割
来源：上海药物研究所
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