Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence
文献类型：期刊论文
| 作者 | Tu, Shanghui1,2; Ding, Chunyong1,3 ; Hu, Wenxiang2; Li, Fulong1,3; Yao, Qizheng3; Zhang, Ao1
|
| 刊名 | MOLECULAR DIVERSITY
 |
| 出版日期 | 2011-02 |
| 卷号 | 15期号:1页码:91-99 |
| 关键词 | Carbazole Anticancer Tandem reaction Coupling reaction Cyclization |
| ISSN号 | 1381-1991 |
| DOI | 10.1007/s11030-010-9241-x |
| 文献子类 | Article |
| 英文摘要 | An efficient three-step approach was developed to assemble indole- or benzofuran-fused benzocarbazole-1,4-diones in 42-53% overall yield. This approach includes AgOAc-promoted oxidative cyclization of 2,6-di-bromocyclohexene-1,4-dione with indol-3-ylpropanoid acid, condensation of the resulting bromocarbazole intermediates with phenols or anilines, followed by Pd(OAc)-catalyzed cyclization. Such convenient synthetic protocol and the novelty of the corresponding products will largely assist our drug design and development program. |
| WOS关键词 | VITRO ANTIPROLIFERATIVE ACTIVITIES ; CHECKPOINT-1 KINASE INHIBITORS ; BIOLOGICAL-ACTIVITIES ; GRANULATIMIDE ANALOGS ; COUPLING REACTIONS ; REBECCAMYCIN ; ANTITUMOR ; CARBAZOLES ; BEARING ; DERIVATIVES |
| 资助项目 | Chinese National Science Foundation[30772625] ; National Science and Technology Major Project on "Key New Drug Creation and Manufacturing Program"[2009ZX09301-001] ; National Science and Technology Major Project on "Key New Drug Creation and Manufacturing Program"[2009ZX09103-062] ; "863" grant[2007AA022163] ; Chinese Academy of Sciences[00000000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000288460200007 |
| 出版者 | SPRINGER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278608]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | 1.SIMM, SOMCL, Shanghai 201203, Peoples R China; 2.Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China; 3.China Pharmaceut Univ, Dept Med Chem, Nanjing 21009, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tu, Shanghui,Ding, Chunyong,Hu, Wenxiang,et al. Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence[J]. MOLECULAR DIVERSITY,2011,15(1):91-99. |
| APA | Tu, Shanghui,Ding, Chunyong,Hu, Wenxiang,Li, Fulong,Yao, Qizheng,&Zhang, Ao.(2011).Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence.MOLECULAR DIVERSITY,15(1),91-99. |
| MLA | Tu, Shanghui,et al."Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence".MOLECULAR DIVERSITY 15.1(2011):91-99. |
入库方式： OAI收割
来源：上海药物研究所
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