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SmI2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched beta-amino acid esters

文献类型：期刊论文

作者Wang Li; Shen Chun; Xu Ming-Hua
刊名SCIENCE CHINA-CHEMISTRY
出版日期2011-01
卷号54期号:1页码:61-65
关键词beta-amino acid ester samarium diiodide N-tert-butanesulfinyl imine Reformatsky reaction beta-lactam 3-aminoindan-1-one asymmetric synthesis
ISSN号1674-7291
DOI10.1007/s11426-010-4180-z
文献子类Article
英文摘要A facile and efficient method for the stereoselective synthesis of beta-amino acid esters via SmI2-promoted imino-Reformatsky reaction is described. Asymmetric addition of tert-butyl bromoacetate to N-tert-butanesulfinyl aldimines afforded beta-amino acid esters in moderate to high yields with excellent diastereoselectivities. The synthetic utilities of the tert-butyl beta-amino acid esters were expanded by the preparation of beta-lactams and 3-aminoindan-1-ones derivatives.
WOS关键词TERT-BUTANESULFINYL IMINES ; CATALYTIC STRECKER REACTION ; ASYMMETRIC-SYNTHESIS ; ENANTIOSELECTIVE SYNTHESIS ; PHOSPHONYL IMINES ; VICINAL DIAMINES ; ONE-POT ; LACTAMS ; INHIBITORS ; CONDENSATION
资助项目National Natural Science Foundation of China[20721003] ; Chinese Academy of Sciences[00000000] ; State Key Laboratory of Drug Research[00000000] ; National Science & Technology Major Project[2009ZX09301-001] ; National Science & Technology Major Project[2008ZX09401-004] ; SIMM[00000000]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000286498200007
出版者SCIENCE PRESS
源URL[http://119.78.100.183/handle/2S10ELR8/278633]  
专题药物化学研究室
通讯作者Xu Ming-Hua
作者单位Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Wang Li,Shen Chun,Xu Ming-Hua. SmI2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched beta-amino acid esters[J]. SCIENCE CHINA-CHEMISTRY,2011,54(1):61-65.
APA Wang Li,Shen Chun,&Xu Ming-Hua.(2011).SmI2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched beta-amino acid esters.SCIENCE CHINA-CHEMISTRY,54(1),61-65.
MLA Wang Li,et al."SmI2-promoted imino-Reformatsky reaction for facile synthesis of enantioenriched beta-amino acid esters".SCIENCE CHINA-CHEMISTRY 54.1(2011):61-65.

入库方式： OAI收割

来源：上海药物研究所

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