Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors
文献类型：期刊论文
| 作者 | Wang, Yuanxiang2; Ai, Jing1 ; Liu, Gang2; Geng, Meiyu1; Zhang, Ao2
|
| 刊名 | ORGANIC & BIOMOLECULAR CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:17页码:5930-5933 |
| ISSN号 | 1477-0520 |
| DOI | 10.1039/c1ob05830d |
| 文献子类 | Article |
| 英文摘要 | An effective one-pot synthesis of quinolines bearing diverse C3-piperazinyl functions was developed by using a modified Friedlander's protocol. The method not only enables the synthesis of our early reported c-Met inhibitor on a large scale, but also provides a way to generate novel multi-substituted quinolines for further structure-activity relationship (SAR) study. |
| WOS关键词 | KINASE ; OPTIMIZATION ; DISCOVERY |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000293756800004 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278672]  |
| 专题 | 药理学第一研究室 药物化学研究室 |
| 通讯作者 | Geng, Meiyu |
| 作者单位 | 1.Chinese Acad Sci, Div Antitumor Pharmacol, SIMM, Shanghai 201203, Peoples R China; 2.Chinese Acad Sci, Synthet Organ & Med Chem Lab, SIMM, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Yuanxiang,Ai, Jing,Liu, Gang,et al. Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2011,9(17):5930-5933. |
| APA | Wang, Yuanxiang,Ai, Jing,Liu, Gang,Geng, Meiyu,&Zhang, Ao.(2011).Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors.ORGANIC & BIOMOLECULAR CHEMISTRY,9(17),5930-5933. |
| MLA | Wang, Yuanxiang,et al."Expeditious one-pot synthesis of C3-piperazinyl-substituted quinolines: key precursors to potent c-Met inhibitors".ORGANIC & BIOMOLECULAR CHEMISTRY 9.17(2011):5930-5933. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。