Synthesis and biological evaluation of novel triptolide analogues for anticancer activity
文献类型：期刊论文
| 作者 | Zhou, Bing ; Miao, Zehong; Deng, Gang; Ding, Jian; Yang, Yaxi; Feng, Huijin; Li, Yuanchao
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2010-11-01 |
| 卷号 | 20期号:21页码:6217-6221 |
| 关键词 | Triptolide Structure-activity relationships 9,11-Olefin Five-membered unsaturated lactam ring A/B cis ring junction |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2010.08.106 |
| 文献子类 | Article |
| 英文摘要 | Three types of novel triptolide analogues with 9,11-olefin (3-5), five-membered unsaturated lactam ring (6-7) or A/B cis ring junction (8-14) were synthesized. Although with 9,11-olefin instead of 9,11-beta-epoxide, compound 4a was much more active than the parent natural triptolide (1) with the lowest IC50 value of 0.05 nM for SKOV-3 cells, clearly challenging the traditional viewpoint on the necessity of 9,11-beta-epoxide group of triptolide. In addition, structure-activity relationships for three classes of compounds were studied. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TRIPTERYGIUM-WILFORDII ; CELLS ; APOPTOSIS ; PG490 ; TRIPDIOLIDE ; ACTIVATION ; PATHWAY ; GROWTH |
| 资助项目 | "Key New Drug Creation and Manufacturing Program", China[2009ZX09102-026] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000282677900013 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278733]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bing,Miao, Zehong,Deng, Gang,et al. Synthesis and biological evaluation of novel triptolide analogues for anticancer activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2010,20(21):6217-6221. |
| APA | Zhou, Bing.,Miao, Zehong.,Deng, Gang.,Ding, Jian.,Yang, Yaxi.,...&Li, Yuanchao.(2010).Synthesis and biological evaluation of novel triptolide analogues for anticancer activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,20(21),6217-6221. |
| MLA | Zhou, Bing,et al."Synthesis and biological evaluation of novel triptolide analogues for anticancer activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20.21(2010):6217-6221. |
入库方式： OAI收割
来源：上海药物研究所
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