Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (-)-triptolide
文献类型：期刊论文
| 作者 | Zhou, Bing1 ; Li, Xiaomei1,2; Feng, Huijin1; Li, Yuanchao1
|
| 刊名 | TETRAHEDRON
 |
| 出版日期 | 2010-07-17 |
| 卷号 | 66期号:29页码:5396-5401 |
| 关键词 | Triptophenolide methyl ether (-)-Triptolide (-)-Triptonide Abietic acid Total synthesis |
| ISSN号 | 0040-4020 |
| DOI | 10.1016/j.tet.2010.05.035 |
| 文献子类 | Article |
| 英文摘要 | An efficient synthesis of triptophenolide methyl ether 4 from the readily available abietic acid 3 in nine steps is described and successfully applied to the synthesis of (-)-triptolide 1. The route is of characteristic of low cost, high yield and easy operation. In addition, every reaction in this route has been successfully scaled-up to a 100 g substrate level without loss of yield. (C) 2010 Elsevier Ltd. All rights reserved. |
| WOS关键词 | TRIPTOLIDE ; TRIPTERYGIUM ; TRIPDIOLIDE ; TRIPTONIDE ; ALPHA ; CELLS |
| 资助项目 | National Science & Technology Major Project 'Key New Drug Creation and Manufacturing Program', China[2009ZX09102-026] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000279766500012 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278829]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shanghai Pharmaceut Grp Co Ltd, Shanghai 200020, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Bing,Li, Xiaomei,Feng, Huijin,et al. Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (-)-triptolide[J]. TETRAHEDRON,2010,66(29):5396-5401. |
| APA | Zhou, Bing,Li, Xiaomei,Feng, Huijin,&Li, Yuanchao.(2010).Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (-)-triptolide.TETRAHEDRON,66(29),5396-5401. |
| MLA | Zhou, Bing,et al."Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (-)-triptolide".TETRAHEDRON 66.29(2010):5396-5401. |
入库方式： OAI收割
来源：上海药物研究所
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