Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives
文献类型：期刊论文
| 作者 | Fu, Li Qiang1; Guo, Xing Sheng2; Liu, Xin1; He, Hui Li1; Wang, Yu Ling2; Yang, Yu She1 |
| 刊名 | CHINESE CHEMICAL LETTERS
 |
| 出版日期 | 2010-05 |
| 卷号 | 21期号:5页码:507-510 |
| 关键词 | Synthesis Pleuromutilin C-2(S)-substituted Antimicrobial activity |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2010.01.001 |
| 文献子类 | Article |
| 英文摘要 | In order to probe the effect of C-2(S)-substituted groups in the antibacterial activity. a series of novel C-2(S)-substituted pleuromutilin analogues of SB-225586 were synthesized and evaluated for then in vitro antibacterial activity. The results of antibacterial activities indicated that C-2(S)-substituted pleuromutilin derivatives retained appreciable antibacterial activity, and the 2-fluorination compounds 6a and 6b are more potent than the corresponding 2-hydroxylation analogues 7a and 7b. (C) 2010 Yu She Yang Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved |
| WOS关键词 | PATHOGENS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000277862400001 |
| 出版者 | ELSEVIER SCIENCE INC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/278906]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Yang, Yu She |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China |
| 推荐引用方式 GB/T 7714 | Fu, Li Qiang,Guo, Xing Sheng,Liu, Xin,et al. Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(5):507-510. |
| APA | Fu, Li Qiang,Guo, Xing Sheng,Liu, Xin,He, Hui Li,Wang, Yu Ling,&Yang, Yu She.(2010).Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives.CHINESE CHEMICAL LETTERS,21(5),507-510. |
| MLA | Fu, Li Qiang,et al."Synthesis and antibacterial activity of C-2(S)-substituted pleuromutilin derivatives".CHINESE CHEMICAL LETTERS 21.5(2010):507-510. |
入库方式： OAI收割
来源：上海药物研究所
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