Concise Asymmetric Synthesis of Antimalarial Alkaloid (+)-Febrifugine
文献类型：期刊论文
| 作者 | Wang, Rui2; Fang, Kai2; Sun, Bing-Feng2; Xu, Ming-Hua1,2 ; Lin, Guo-Qiang2
|
| 刊名 | SYNLETT
 |
| 出版日期 | 2009-09-01 |
| 期号 | 14页码:2301-2304 |
| 关键词 | antimalarial asymmetric synthesis febrifugine cross-coupling |
| ISSN号 | 0936-5214 |
| DOI | 10.1055/s-0029-1217713 |
| 文献子类 | Article |
| 英文摘要 | An asymmetric total synthesis of antimalarial alkaloid (+)-febrifugine is accomplished in 23% overall yield over 14 steps from readily available starting materials. The synthesis features a Sml(2)-mediated reductive cross-coupling of chiral N-tert-butanesulfinyl imine with aldehyde. |
| WOS关键词 | TERT-BUTANESULFINYL IMINES ; SULFOXIDE-TRIFLUOROACETIC ANHYDRIDE ; RING-OPENING REACTIONS ; ENANTIOSELECTIVE SYNTHESIS ; VICINAL DIAMINES ; YEAST REDUCTION ; FEBRIFUGINE ; ISOFEBRIFUGINE ; ALCOHOLS ; ALDEHYDES |
| 资助项目 | Major State Basic Research Development Program[2006CB806106] ; Chinese Academy of Sciences[KSCX2-YW-R-23] ; Chinese Academy of Sciences[07JC140063] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000271022900016 |
| 出版者 | GEORG THIEME VERLAG KG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279152]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Xu, Ming-Hua |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Rui,Fang, Kai,Sun, Bing-Feng,et al. Concise Asymmetric Synthesis of Antimalarial Alkaloid (+)-Febrifugine[J]. SYNLETT,2009(14):2301-2304. |
| APA | Wang, Rui,Fang, Kai,Sun, Bing-Feng,Xu, Ming-Hua,&Lin, Guo-Qiang.(2009).Concise Asymmetric Synthesis of Antimalarial Alkaloid (+)-Febrifugine.SYNLETT(14),2301-2304. |
| MLA | Wang, Rui,et al."Concise Asymmetric Synthesis of Antimalarial Alkaloid (+)-Febrifugine".SYNLETT .14(2009):2301-2304. |
入库方式： OAI收割
来源：上海药物研究所
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