Design of Multivalent Ligand Targeting G-Protein-Coupled Receptors
文献类型：期刊论文
| 作者 | Liu, Zhili; Zhang, Jing; Zhang, Ao
|
| 刊名 | CURRENT PHARMACEUTICAL DESIGN
 |
| 出版日期 | 2009-02 |
| 卷号 | 15期号:6页码:682-718 |
| 关键词 | Multivalent ligand G-protein-coupled receptors (GPCRs) drug design and development heterodimerization Parkinson's disease Alzheimer's disease schizophrenia drug abuse drug target |
| ISSN号 | 1381-6128 |
| DOI | 10.2174/138161209787315639 |
| 文献子类 | Review |
| 英文摘要 | More and more evidences are still accumulating rapidly on the G-protein-coupled-receptors (GPCRs) dimerization/oligomerization. Such common feature of GPCRs has called extensive attention to both pharmacologists and medicinal chemists for illustration of the pharmacological functions and therapeutic utilities of such receptor complex. Although there is still no clear explanation for the receptor dimerization/oligomerization, a large number of multivalent ligands (MLs) have been designed to target the receptor-dimers/oligomers. Such MLs have gained much acceptance in exploring the receptor complex of dopaminergic, adrenergic, serotoninergic, and opioidic receptor systems, due to the relatively broader experience in recognizing the receptor-dimerization. More and more MLs have also been designed to face GPCR-related very complex neurodegenerative diseases, such as Parkinson's disease (PD), Alzheimer's disease (AD) and schizophrenia, which are not effectively treated by traditional highly selective drugs. Herein, some of the most recent developments in this field, as well as some typical examples of MLs, are highlighted, with a particular focus on GPCRs. |
| WOS关键词 | RESONANCE ENERGY-TRANSFER ; ATYPICAL ANTIPSYCHOTIC AGENTS ; HISTAMINE H-3 ANTAGONISTS ; DUAL 5-HT1A RECEPTOR ; MU-OPIOID RECEPTOR ; SEROTONIN REUPTAKE INHIBITORS ; ANGIOTENSIN-II RECEPTORS ; POTENT ACETYLCHOLINESTERASE INHIBITORS ; FUNCTIONAL HETEROMERIC COMPLEXES ; CLONIDINE-DISPLACING SUBSTANCE |
| 资助项目 | Hundred Talent Project of the Chinese Academy of Sciences[00000000] ; Chinese National Science Foundation[30772625] ; Shanghai Commission of Science and Technology[07pj14104] ; State Key Laboratory of Drug Research[SIMM0809KF-02] ; Shanghai Institute of Materia Medica[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000263963700008 |
| 出版者 | BENTHAM SCIENCE PUBL LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279328]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Zhang, Ao |
| 作者单位 | Chinese Acad Sci, SIMM, SOMCL, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Zhili,Zhang, Jing,Zhang, Ao. Design of Multivalent Ligand Targeting G-Protein-Coupled Receptors[J]. CURRENT PHARMACEUTICAL DESIGN,2009,15(6):682-718. |
| APA | Liu, Zhili,Zhang, Jing,&Zhang, Ao.(2009).Design of Multivalent Ligand Targeting G-Protein-Coupled Receptors.CURRENT PHARMACEUTICAL DESIGN,15(6),682-718. |
| MLA | Liu, Zhili,et al."Design of Multivalent Ligand Targeting G-Protein-Coupled Receptors".CURRENT PHARMACEUTICAL DESIGN 15.6(2009):682-718. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。