Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity
文献类型：期刊论文
| 作者 | Xie, Fuchun; Zhao, Hongbing; Zhao, Lizhi; Lou, Liguang ; Hu, Youhong
|
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
 |
| 出版日期 | 2009 |
| 卷号 | 19期号:1页码:275-278 |
| 关键词 | Pyrimidine Anticancer BEL-7402 |
| ISSN号 | 0960-894X |
| DOI | 10.1016/j.bmcl.2008.09.067 |
| 文献子类 | Article |
| 英文摘要 | A series of novel 2,4,5-substituted pyrimidine derivatives were synthesized and evaluated for inhibition against the human hepatocellular carcinoma BEL-7402 cancer cell line. Several compounds showed potent inhibition with an IC50 value less than 0.10 mu M. Structure-activity relationships for this class of compounds at the 2- and 5-position of the pyrimidine scaffold have been elucidated. The most active compound 7gc showed good inhibition of several different human cancer cell lines with IC50 values from 0.024 to 0.55 mu M. (C) 2008 Elsevier Ltd. All rights reserved. |
| WOS关键词 | RECEPTOR ANTAGONISTS ; INHIBITORS ; POTENT ; DISCOVERY |
| 资助项目 | Shanghai Commission of Science and Technology[06PJ14112] ; Chinese Academy of Sciences[KSCX-2-YW-R-23] |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000261908600060 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279352]  |
| 专题 | 药理学第一研究室 药物化学研究室 |
| 通讯作者 | Lou, Liguang |
| 作者单位 | Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xie, Fuchun,Zhao, Hongbing,Zhao, Lizhi,et al. Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(1):275-278. |
| APA | Xie, Fuchun,Zhao, Hongbing,Zhao, Lizhi,Lou, Liguang,&Hu, Youhong.(2009).Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(1),275-278. |
| MLA | Xie, Fuchun,et al."Synthesis and biological evaluation of novel 2,4,5-substituted pyrimidine derivatives for anticancer activity".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.1(2009):275-278. |
入库方式： OAI收割
来源：上海药物研究所
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