Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water
文献类型：期刊论文
| 作者 | Zhang, Xiaodong1; Ye, Deju1; Sun, Haifeng1; Guo, Diliang1; Wang, Jiang1 ; Huang, He1; Zhang, Xu1; Jiang, Hualiang1,2; Liu, Hong1
|
| 刊名 | GREEN CHEMISTRY
 |
| 出版日期 | 2009 |
| 卷号 | 11期号:11页码:1881-1888 |
| ISSN号 | 1463-9262 |
| DOI | 10.1039/b916124b |
| 文献子类 | Article |
| 英文摘要 | A green, rapid, and efficient method was developed for synthesizing quinazolinone derivatives from substituted 2-halobenzoic acids and amidines via microwave-assisted iron-catalyzed cyclization with or without ligand in water (methods A and B) or DMF (methods C and D). With these methods, moderate to high yields of the desired products can be obtained from even inactive substrates, such as guanidines. To the best of our knowledge, this is the first report on the synthesis of N-heterocyclic compounds by iron-catalyzed C-N coupling in aqueous media. |
| WOS关键词 | CROSS-COUPLING REACTIONS ; NITROGEN NUCLEOPHILES ; ARYL HALIDES ; ORGANIC-REACTIONS ; AQUEOUS-MEDIA ; N-ARYLATIONS ; CHEMISTRY ; ALKALOIDS ; CHLORIDE ; AMINES |
| 资助项目 | National Natural Science Foundation of China[20721003] ; National Natural Science Foundation of China[20872153] ; International Collaboration Projects[2007DFB30370] ; International Collaboration Projects[20720102040] ; 863 Hi-Tech Program of China[2006AA020602] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000271476500028 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279367]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Liu, Hong |
| 作者单位 | 1.Chinese Acad Sci 1, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr,State Key Lab Drug Re, Shanghai 201203, Peoples R China; 2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Xiaodong,Ye, Deju,Sun, Haifeng,et al. Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water[J]. GREEN CHEMISTRY,2009,11(11):1881-1888. |
| APA | Zhang, Xiaodong.,Ye, Deju.,Sun, Haifeng.,Guo, Diliang.,Wang, Jiang.,...&Liu, Hong.(2009).Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water.GREEN CHEMISTRY,11(11),1881-1888. |
| MLA | Zhang, Xiaodong,et al."Microwave-assisted synthesis of quinazolinone derivatives by efficient and rapid iron-catalyzed cyclization in water".GREEN CHEMISTRY 11.11(2009):1881-1888. |
入库方式： OAI收割
来源：上海药物研究所
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