A NEW METHOD TO SYNTHESIZE FAMCICLOVIR
文献类型：期刊论文
| 作者 | Luo, Lei1; Chen, Guorong1; Li, Yuanchao2 |
| 刊名 | HETEROCYCLES
 |
| 出版日期 | 2008-11-01 |
| 卷号 | 75期号:11页码:2803-+ |
| 关键词 | Mitsunobu Reaction Antiviral Drug Synthesis |
| ISSN号 | 0385-5414 |
| 文献子类 | Article |
| 英文摘要 | A new and efficient method has been reported for the synthesis of 2-amino-9-[4-acetoxy-3-(acetoxymethyl)butyl-1-yl]purine (famciclovir) starting from guanine. The route involves chlorination of guanine, optimized Mitsunobu reaction, coupling with diethyl malonate, hydrogenation, reduction and esterification, and the overall yield is about 29%. This method does not require any form of chromatographic purification to give pure famciclovir, and it is an industrially viable manufacturing process for this drug. |
| WOS关键词 | PENCICLOVIR ; ANALOGS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000261352200015 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279452]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Li, Yuanchao |
| 作者单位 | 1.E China Univ Sci & Technol, Inst Fine Chem, Adv Mat Lab, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Luo, Lei,Chen, Guorong,Li, Yuanchao. A NEW METHOD TO SYNTHESIZE FAMCICLOVIR[J]. HETEROCYCLES,2008,75(11):2803-+. |
| APA | Luo, Lei,Chen, Guorong,&Li, Yuanchao.(2008).A NEW METHOD TO SYNTHESIZE FAMCICLOVIR.HETEROCYCLES,75(11),2803-+. |
| MLA | Luo, Lei,et al."A NEW METHOD TO SYNTHESIZE FAMCICLOVIR".HETEROCYCLES 75.11(2008):2803-+. |
入库方式： OAI收割
来源：上海药物研究所
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