Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery
文献类型：期刊论文
| 作者 | Shou, Kangquan2,3; Tang, Yufu4; Chen, Hao3; Chen, Si3; Zhang, Lei3; Zhang, Ao1 ; Fan, Quli4; Yu, Aixi2; Cheng, Zhen3
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| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2018-03-28 |
| 卷号 | 9期号:12页码:3105-3110 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/c8sc00206a |
| 文献子类 | Article |
| 英文摘要 | A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000-1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution. Overall, excellent biocompatibility, favorable hydrophilicity, and desirable chemical and optical properties make the semiconducting polymer nanoparticle PDFT1032 a highly promising NIR-II imaging probe with the potential to be widely applicable in clinical imaging and the surgical treatment of malignancy. |
| WOS关键词 | FLUORESCENCE ; EMISSION ; THERAPY ; BRAIN ; DYE |
| 资助项目 | Office of Science (BER), U.S. Department of Energy[DE-SC0008397] ; International Cooperative Program of the Chinese Academy of Sciences[GJHZ1622] ; National Basic Research Program of China[2012CB933301] ; National Natural Science Foundation of China[21674048] ; National Natural Science Foundation of China[21574064] ; National Natural Science Foundation of China[81572163] ; National Natural Science Foundation of China[61378081] ; Synergetic Innovation Center for Organic Electronics and Information Displays[00000000] ; Natural Science Foundation of Jiangsu Province of China[NY211003] ; Huanghe Talents Project of Wuhan City[00000000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000428987200003 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279837]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Fan, Quli; Yu, Aixi; Cheng, Zhen |
| 作者单位 | 1.Chinese Acad Sci, CAS Key Lab Receptor Res, Pudong New Area,SOMCL, Shanghai Inst Mat Med, 555 Zuchong Rd, Shanghai 201203, Peoples R China 2.Wuhan Univ, Zhongnan Hosp, Dept Orthoped, Wuhan 430071, Hubei, Peoples R China; 3.Stanford Univ, MIPS, Bio X Program, Dept Radiol,Canary Ctr Stanford Canc Early Detect, Stanford, CA 94305 USA; 4.Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Inst Adv Mat, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Nanjing 210023, Jiangsu, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Shou, Kangquan,Tang, Yufu,Chen, Hao,et al. Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery[J]. CHEMICAL SCIENCE,2018,9(12):3105-3110. |
| APA | Shou, Kangquan.,Tang, Yufu.,Chen, Hao.,Chen, Si.,Zhang, Lei.,...&Cheng, Zhen.(2018).Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery.CHEMICAL SCIENCE,9(12),3105-3110. |
| MLA | Shou, Kangquan,et al."Diketopyrrolopyrrole-based semiconducting polymer nanoparticles for in vivo second near-infrared window imaging and image-guided tumor surgery".CHEMICAL SCIENCE 9.12(2018):3105-3110. |
入库方式： OAI收割
来源：上海药物研究所
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