Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice
文献类型：期刊论文
| 作者 | Yu, Hanjie2,3,4; Li, Mengmeng2,3,4; Zhou, Dongsheng5; Lv, Dan2,3,4; Liao, Qi2,3,4; Lou, Zhongze6; Shen, Mengxin2,3,4; Wang, Zhen7 ; Li, Ming1,8; Xiao, Xiao1,8
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| 刊名 | NEUROPHARMACOLOGY
 |
| 出版日期 | 2018-03-15 |
| 卷号 | 131页码:209-222 |
| ISSN号 | 0028-3908 |
| 关键词 | Scopolamine alpha-Amino-3-1-lydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) Vesicular glutamate transporter 1 (VGLUT1) Brain-derived neurotrophic factor (BDNF) VGF (non-acronymic) Bicaudal C homolog 1 gene (BICC1) |
| DOI | 10.1016/j.neuropharm.2017.12.028 |
| 文献子类 | Article |
| 英文摘要 | Emerging data have identified certain drugs such as scopolamine as rapidly acting antidepressants for major depressive disorder (MDD) that increase glutamate release and induce neurotrophic factors through alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) activation in rodent models. However, little research has addressed the direct mechanisms of scopolamine on AMPAR activation or vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release in the prefrontal cortex (PFC) of mice. Herein, using a chronic unpredictable stress (CUS) paradigm, acute treatment with scopolamine rapidly reversed stress-induced depression-like behaviors in mice. Our results showed that CUS-induced depression-like behaviors, accompanied by a decrease in membrane AMPAR subunit 1 (GluA1), phosphorylated GluA1 Ser845 (pGluA1 Ser845), brain-derived neurotrophic factor (BDNF) and VGF (non-acronymic) and an increase in bicaudal C homolog 1 gene (BICC1) in the PFC of mice, and these biochemical and behavioral abnormalities were ameliorated by acute scopolamine treatments. However, pharmacological block of AMPAR by NBQX infusion into the PFC significantly abolished these effects of scopolamine. In addition, knock down of VGLUT1 by lentiviral-mediated RNA interference in the PFC of mice was sufficient to induce depression-like phenotype, to decrease extracellular glutamate accumulation and to cause similar molecular changes with CUS in mice. Remarkably, VGLUT1 knockdown alleviated the rapid antidepressant-like actions of scopolamine and the effects of scopolamine on membrane GluA1-mediated BDNF, VGF and BICC1 changes. Altogether, our findings suggest that VGLUT1-mediated glutamate release and membrane GluA1 activation may play a critical role in the rapid-acting antidepressant-like effects of scopolamine in mice. (C) 2017 Elsevier Ltd. All rights reserved. |
| WOS关键词 | MAJOR DEPRESSIVE DISORDER ; MEDIAL PREFRONTAL CORTEX ; ACTING ANTIDEPRESSANTS ; RECEPTOR ANTAGONIST ; MUSCARINIC RECEPTORS ; SYNAPTIC PLASTICITY ; MAMMALIAN TARGET ; MOOD DISORDERS ; GENE VGF ; KETAMINE |
| 资助项目 | National Natural Science Foundation of China[81671337] ; National Natural Science Foundation of China[81201050] ; Natural Science Foundation of Zhejiang province[LQ12H09001] ; Natural Science Foundation of Ningbo[2017A610212] ; Natural Science Foundation of Ningbo[2016A610156] ; Ningbo Municipal Innovation Team of Life Science and Health[2015C110026] ; National Undergraduate Training Program for Innovation and Entrepreneurship[201711646017] ; Xinmiao Talents Program of Zhejiang[2017R405030] ; Student Research and Innovation Program (SIRP)[00000000] ; K.C. Wong Magna in Ningbo University[00000000] |
| WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000427316000020 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/279849]  |
| 专题 | 药物化学研究室 |
| 通讯作者 | Wang, Chuang |
| 作者单位 | 1.Chinese Acad Sci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China 2.Ningbo Univ, Sch Med, Ningbo Key Lab Behav Neurosci, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China; 3.Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathophysiol, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China; 4.Ningbo Univ, Sch Med, Dept Physiol & Pharmacol, 818 Fenghua Rd, Ningbo 315211, Zhejiang, Peoples R China; 5.Ningbo Kangning Hosp, Ningbo 315201, Zhejiang, Peoples R China; 6.Ningbo First Hosp, Dept Psychosomat Med, 59 Liuting Str, Ningbo 315010, Zhejiang, Peoples R China; 7.Chinese Acad Sci, CAS Key Lab Receptor Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 8.Chinese Acad Sci & Yunnan Prov, Key Lab Anim Models & Human Dis Mech, Kunming Inst Zool, 32 East Jiao Chang Rd, Kunming 650223, Yunnan, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Yu, Hanjie,Li, Mengmeng,Zhou, Dongsheng,et al. Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice[J]. NEUROPHARMACOLOGY,2018,131:209-222. |
| APA | Yu, Hanjie.,Li, Mengmeng.,Zhou, Dongsheng.,Lv, Dan.,Liao, Qi.,...&Wang, Chuang.(2018).Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice.NEUROPHARMACOLOGY,131,209-222. |
| MLA | Yu, Hanjie,et al."Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice".NEUROPHARMACOLOGY 131(2018):209-222. |
入库方式： OAI收割
来源：上海药物研究所
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