Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica
文献类型：期刊论文
| 作者 | Feng, Tao2; Duan, Kai-Ting2; He, Shi-Jun1 ; Wu, Bin2; Zheng, Yong-Sheng2; Ai, Hong-Lian2; Li, Zheng-Hui2; He, Juan2; Zuo, Jian-Ping1; Liu, Ji-Kai2
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| 刊名 | Organic letters
 |
| 出版日期 | 2018-12-10 |
| ISSN号 | 1523-7052 |
| DOI | 10.1021/acs.orglett.8b03489 |
| 文献子类 | Article |
| 英文摘要 | Two monoterpenoid indole alkaloids, ophiorrhines A (1) and B (2), were obtained from plant Ophiorrhiza japonica BI. Their structures were elucidated by extensive spectroscopic methods and single crystal X-ray diffraction. Compounds 1 and 2 possess a novel spirocyclic ring system. Its biosynthesis pathway is proposed. Compound 2 exhibits potent inhibitory activity against concanavalin A (Con A) induced T cell proliferation and lipopolysaccharide (LPS) induced B lymphocyte cell proliferation with IC values 13.3 and 7.5 μM, respectively. Compound 1 exhibits significant inhibition specifically against the LPS-induced proliferation of B lymphocyte cells with IC value 18.6 μM. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266318]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 1.State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China 2.School of Pharmaceutical Sciences , South-Central University for Nationalities , Wuhan 430074 , China; |
| 推荐引用方式 GB/T 7714 | Feng, Tao,Duan, Kai-Ting,He, Shi-Jun,et al. Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica[J]. Organic letters,2018. |
| APA | Feng, Tao.,Duan, Kai-Ting.,He, Shi-Jun.,Wu, Bin.,Zheng, Yong-Sheng.,...&Liu, Ji-Kai.(2018).Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica.Organic letters. |
| MLA | Feng, Tao,et al."Ophiorrhines A and B, Two Immunosuppressive Monoterpenoid Indole Alkaloids from Ophiorrhiza japonica".Organic letters (2018). |
入库方式： OAI收割
来源：上海药物研究所
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