Iron Metabolism in Cancer
文献类型：期刊论文
| 作者 | Wang, Yafang; Yu, Lei; Ding, Jian ; Chen, Yi
|
| 刊名 | International journal of molecular sciences
 |
| 出版日期 | 2018-12-27 |
| 卷号 | 20期号:1 |
| ISSN号 | 1422-0067 |
| DOI | 10.3390/ijms20010095 |
| 文献子类 | Article;Review |
| 英文摘要 | Demanded as an essential trace element that supports cell growth and basic functions, iron can be harmful and cancerogenic though. By exchanging between its different oxidized forms, iron overload induces free radical formation, lipid peroxidation, DNA, and protein damages, leading to carcinogenesis or ferroptosis. Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a considerable approach for cancer therapy. Several iron chelators and iron oxide nanoparticles (IONPs) has recently been developed for cancer intervention and presented considerable effects. This review summarizes some latest findings about iron metabolism function and regulation mechanism in cancer and the application of iron chelators and IONPs in cancer diagnosis and therapy. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266706]  |
| 专题 | 新药研究国家重点实验室 药理学第一研究室 |
| 通讯作者 | Wang, Yafang; Yu, Lei; Ding, Jian; Chen, Yi |
| 作者单位 | Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China |
| 推荐引用方式 GB/T 7714 | Wang, Yafang,Yu, Lei,Ding, Jian,et al. Iron Metabolism in Cancer[J]. International journal of molecular sciences,2018,20(1). |
| APA | Wang, Yafang,Yu, Lei,Ding, Jian,&Chen, Yi.(2018).Iron Metabolism in Cancer.International journal of molecular sciences,20(1). |
| MLA | Wang, Yafang,et al."Iron Metabolism in Cancer".International journal of molecular sciences 20.1(2018). |
入库方式： OAI收割
来源：上海药物研究所
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