Synthesis and antitumor activity of a series of lactone-opened camptothecin derivatives
文献类型：期刊论文
| 作者 | Zheng, Chao3; Li, Ming-Zong2; You, Tian-Pa2; Tang, Wei-Ping1; Lou, Li-Guang1
|
| 刊名 | Journal of Asian natural products research
 |
| 出版日期 | 2017-10-24 |
| 页码 | 1-11 |
| ISSN号 | 1477-2213 |
| DOI | 10.1080/10286020.2017.1392941 |
| 文献子类 | Article |
| 英文摘要 | A series of E-ring lactone-opened camptothecin (CPT) derivatives bearing with terminal aza-heterocyclic groups were synthesized, and their antitumor activity was evaluated both in vitro and in vivo. Hydroxyl-amide analogues with morpholin-4-yl displayed excellent antitumor activity in vitro and efficient inhibition on tumor xenograph model in nude mice. Ester-amide compounds acted less active in vitro cytotoxicity and lower inhibition activity in vivo. Substitutions at 7- and 10- positions favored the antitumor activity. |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266788]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 1.c Shanghai Institute of Materia Medica, Chinese Academy of Science , Shanghai 201203 , China 2.b Department of Chemistry , University of Science & Technology of China , Hefei 230026 , China; 3.a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Collaborative Innovation Center of Tropical Biological Resources , Hainan Normal University , Haikou 571158 , China; |
| 推荐引用方式 GB/T 7714 | Zheng, Chao,Li, Ming-Zong,You, Tian-Pa,et al. Synthesis and antitumor activity of a series of lactone-opened camptothecin derivatives[J]. Journal of Asian natural products research,2017:1-11. |
| APA | Zheng, Chao,Li, Ming-Zong,You, Tian-Pa,Tang, Wei-Ping,&Lou, Li-Guang.(2017).Synthesis and antitumor activity of a series of lactone-opened camptothecin derivatives.Journal of Asian natural products research,1-11. |
| MLA | Zheng, Chao,et al."Synthesis and antitumor activity of a series of lactone-opened camptothecin derivatives".Journal of Asian natural products research (2017):1-11. |
入库方式： OAI收割
来源：上海药物研究所
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