Chemical preparation and biological evaluation of novel lipophilic platinum(II) complexes of salicylate derivatives
文献类型：会议论文
| 作者 | Liu, Wei-Ping2; Lou, Li-Guang1 ; Ye, Qing-Song2; Yu, Yao2; Chen, Xi-Zhu2; Hou, Shu-Qian2
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| 出版日期 | 2007 |
| 卷号 | 1 |
| 页码 | 324-336 |
| 英文摘要 | A s eri es of novel lipophilic platinum(II) complexes containing salicylate derivatives as the leaving group were synthesized and characterized by elemental analysis, FAB+-MS, FT-IR and1H NMR spectroscopy. The chemical structural parameters were also calculated using DFT(B3LYP). Most of the resulting platinum complexes exhibited high solubility in organic solvents such as ethanol, acetone and ether, and had right partition coefficient suited to be encapsulated in liposomes. The pertinent complexes were evaluated for their in vitro cytotoxicity against A549 human lung carcinoma and SGC-7901 human gastric carcinoma cell lines, and for the in vivo antitumor activity on S180 or non-small cell lung tumors of mice. Two of the complexes, Compound 6 and 8, were found to be more active and less toxic than carboplatin and oxaliplatin, showing great potential to be developed as anticancer agents. |
| 会议录 | 31st Annual Conference of the International Precious Metals Institute 2007 and Petroleum Refining Seminar 2006
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| 会议录出版者 | International Precious Metals Institute |
| 文献子类 | Proceedings Paper |
| 语种 | 英语 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/266857]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Liu, Wei-Ping |
| 作者单位 | 1.Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai, China 2.Platinum-Based Drug Lab., Kunming Institute of Precious Metals, 650021, China; |
| 推荐引用方式 GB/T 7714 | Liu, Wei-Ping,Lou, Li-Guang,Ye, Qing-Song,et al. Chemical preparation and biological evaluation of novel lipophilic platinum(II) complexes of salicylate derivatives[C]. 见:. |
入库方式： OAI收割
来源：上海药物研究所
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