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Characterization and Pharmacokinetics of Dimethyl-beta-cyclodextrin Inclusion Complexes of Water Insoluble Drug BMCP25 in Rats

文献类型：期刊论文

作者Chen Shuijuan2; Fu Dongjun2; Gao Shanshan2; Gao Feng1; Zuo Jianping3
刊名Chinese Journal of Pharmaceuticals
出版日期2013
卷号44期号:2页码:171-174
关键词BMCP25 water insoluble drug BMCP25 2,6-di-O-methyl-beta-yclodextrin inclusion characterization pharmacokinetics
ISSN号1001-8255
其他题名难溶性药物BMCP25二甲基-beta-环糊精包合物的表征及在大鼠体内的药动学
文献子类Article
英文摘要The inclusion complexes of a water insoluble drug BMCP25 (1) with 2,6-di-O-methyl-b- cyclodextrin (DM-beta-CD) were prepared by grinding method. The results of X-ray diffraction and scanning electron microscopy indicated that the drug in inclusion was changed to amorphous phase from the needle-like crystalline phase. The solubilities of 1 before and after inclusion were (0.360.08) and (123.829.81) mug/ml. An HPLC method was established for the determination of 1 in rat plasma. The pharmacokinetics of 1 in rats after iv administration (2 mg/kg) of 1 suspension or ig administration (10 mg/kg) of 1 suspension or its inclusion solution were investigated. After ig administration, the drug concentration in rat plasma was below the limit of detection in the 1 suspension group, while the oral bioavailability of 1-DM-b-CD inclusion complexes was (16.845.88)%. It indicated that the 1-DM-b-CD inclusion complexes could signifi cantly enhance oral bioavailability of 1.
资助项目上海市科学技术委员会项目资助[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4784175
源URL[http://119.78.100.183/handle/2S10ELR8/267789]  
专题药理学第一研究室
作者单位1.Shanghai Key Lab.of New Drug Design,East China University of Science and Technology;
2.Dept.of Pharmaceutics,School of Pharmacy,East China University of Science and Technology, Shanghai 200237, China.;
3.State Key Lab.of Drug Research,Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
4.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 200237, China.;
推荐引用方式
GB/T 7714		 Chen Shuijuan,Fu Dongjun,Gao Shanshan,et al. Characterization and Pharmacokinetics of Dimethyl-beta-cyclodextrin Inclusion Complexes of Water Insoluble Drug BMCP25 in Rats[J]. Chinese Journal of Pharmaceuticals,2013,44(2):171-174.
APA Chen Shuijuan,Fu Dongjun,Gao Shanshan,Gao Feng,&Zuo Jianping.(2013).Characterization and Pharmacokinetics of Dimethyl-beta-cyclodextrin Inclusion Complexes of Water Insoluble Drug BMCP25 in Rats.Chinese Journal of Pharmaceuticals,44(2),171-174.
MLA Chen Shuijuan,et al."Characterization and Pharmacokinetics of Dimethyl-beta-cyclodextrin Inclusion Complexes of Water Insoluble Drug BMCP25 in Rats".Chinese Journal of Pharmaceuticals 44.2(2013):171-174.

入库方式： OAI收割

来源：上海药物研究所

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