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Pharmacokinetics of Adefovir Dipivoxil Tablets in Chinese Healthy Subjects

文献类型：期刊论文

作者Xi Peiying1; Zhang Yunxuan1; Shi Xiaojin1; Li Zhongdong1; Chen Miaoying1; Chen Xiaoyan2; Zhong Dafang2
刊名Chinese Pharmaceutical Journal
出版日期2012
卷号47期号:19页码:1570-1573
关键词adefovir dipivoxil adefovir pharmacokinetics LC-MS/MS
ISSN号1001-2494
其他题名中国健康志愿者单次和多次口服阿德福韦酯片的药动学
文献子类Article
英文摘要OBJECTIVE To investigate the pharmacokinetics of 10 mg adefovir dipivoxil tablet formulations in 12 Chinese healthy subjects after a single dose and multiple doses. METHODS A single dose and multiple doses of the formulations of adefovir dipivoxil tablets were given to each of 12 healthy male subjects. The concentrations of adefovir in plasma were determined by LC-MS/ MS. The pharmacokinetic parameters were calculated by DAS2. 0 programme. RESULTS The obtained pharmacokinetic parameters of adefovir following adefovir dipivoxil tablets in a single dose and multiple doses group were as follows: rho_(max) were (249), (248) mug·L~(-1); AUC_(0-24h) were (210 54), (213 73) mug·h·L~(-1); AUC_(0-) were(236 64), (250 90) mug?h?L~(-1);t_(1/2) were (7.4 1.2), (8.5 2.1) h; t_(max) were (1.30.7),(1.50.6)h,respectively. Other main parameters in multiple doses group were rho_(av)~(ss) (8.90 3.06) mug·L~(-1) and DF (2.52 0. 66). CONCLUSION There was no significant difference in pharmacokinetic parameters between single dose and multi-dose group. There is no accumulation following multiple doses of adefovir dipivoxil. Adefovir dipivoxil tablets were safe and well tolerated in Chinese subjects.
资助项目国家科技重大专项课题资助编号[00000000]
WOS研究方向Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4683998
源URL[http://119.78.100.183/handle/2S10ELR8/267810]  
专题上海药物代谢研究中心
作者单位1.Pharmacy of Huashan. Hospital, Fudan University, Shanghai 200040, China.;
2.Center for Drug Metabolism. Research Shanghai Institute of Meteria Medica Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式
GB/T 7714		 Xi Peiying,Zhang Yunxuan,Shi Xiaojin,et al. Pharmacokinetics of Adefovir Dipivoxil Tablets in Chinese Healthy Subjects[J]. Chinese Pharmaceutical Journal,2012,47(19):1570-1573.
APA Xi Peiying.,Zhang Yunxuan.,Shi Xiaojin.,Li Zhongdong.,Chen Miaoying.,...&Zhong Dafang.(2012).Pharmacokinetics of Adefovir Dipivoxil Tablets in Chinese Healthy Subjects.Chinese Pharmaceutical Journal,47(19),1570-1573.
MLA Xi Peiying,et al."Pharmacokinetics of Adefovir Dipivoxil Tablets in Chinese Healthy Subjects".Chinese Pharmaceutical Journal 47.19(2012):1570-1573.

入库方式： OAI收割

来源：上海药物研究所

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