Acute toxicity of sodium houttuyfonate in BALB/c mice and its injury to cells
文献类型：期刊论文
| 作者 | Lou Xiwen; Luan Yang; Jiang Baohong ; Chen Xiaoyan; Zhong Dafang
|
| 刊名 | Chinese Journal of Pharmacology and Toxicology
 |
| 出版日期 | 2012 |
| 卷号 | 26期号:5页码:653-657 |
| 关键词 | houttuynia cordata acute toxicity hemolysis |
| ISSN号 | 1000-3002 |
| 其他题名 | 鱼腥草素钠对BALB/c小鼠的急性毒性及其对细胞的损伤 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To evaluate the acute toxicity of sodium houttuyfonate (SH) ip given to BALB/c mice and its injury. METHODS BALB/c mice were ip given SH 50,125 and 200 mg·kg~(-1) and the immediate reactions of the mice were observed. Cases of death were counted in SH groups. Histochemistry experiments were performed to observe changes of organs. The concentrations of histamine in plasma of mice were measured. Then the release of lactate dehydrogenase and histamine in peritoneal cells incubated with SH in vitro was measured. The effect of SH on human red blood cells was observed by the hemolysis test. RESULTS When BALB/c mice were ip given SH 50 mg·kg~(-1), there were no death cases observed. Six of the ten mice died in SH 125 mg'kg~(-1) group, accompanied by liver congestion. All the ten mice died in SH 200 mg-kg~(-1) group. Compared with normal control (45.89.6)mug·L~(-1), histamine content in plasma of mice in SH 125 mg.kg~(-1) group was (66.13.9)mug·L~(-1) (P<0.05). Moreover, when peritoneal cells were stimulated with SH 0,32 and 128 ng·L~(-1) in vitro, the concentration of lactate dehydrogenase was 1.21.1, 19.23.3, and 30.63.1 (P<0.01) and the concentration of histamine was 36.59.0,73.33.8 and (82.73.6)mug·L~(-1)(P<0.01), respectively. Furthermore, in vitro hemolysis experiment demonstrates that SH caused obvious hemolysis of human red blood cells. CONCLUSION SH can cause moderate toxicity when ip given to BALB/c mice, which may be related to release of the lactate dehydrogenase and histamine and hemolysis. |
| 资助项目 | 国家自然科学基金[00000000] ; 中国博士后科学基金[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy ; General & Internal Medicine (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4682114 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267811]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | Department of Drug Metabolism, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Lou Xiwen,Luan Yang,Jiang Baohong,et al. Acute toxicity of sodium houttuyfonate in BALB/c mice and its injury to cells[J]. Chinese Journal of Pharmacology and Toxicology,2012,26(5):653-657. |
| APA | Lou Xiwen,Luan Yang,Jiang Baohong,Chen Xiaoyan,&Zhong Dafang.(2012).Acute toxicity of sodium houttuyfonate in BALB/c mice and its injury to cells.Chinese Journal of Pharmacology and Toxicology,26(5),653-657. |
| MLA | Lou Xiwen,et al."Acute toxicity of sodium houttuyfonate in BALB/c mice and its injury to cells".Chinese Journal of Pharmacology and Toxicology 26.5(2012):653-657. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。