Role of transporters in hepatic drug disposition
文献类型：期刊论文
| 作者 | Gao Chunying; Chen Xiaoyan ; Zhong Dafang
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2012 |
| 卷号 | 47期号:5页码:565-572 |
| 关键词 | hepatic clearance transporter drug-drug interaction |
| ISSN号 | 0513-4870 |
| 其他题名 | 转运体在药物经肝脏清除过程中的作用 |
| 文献子类 | Review |
| 英文摘要 | Liver is regarded as one of the most important organs for drug clearance in the body,which mediates both the metabolism and biliary excretion of drugs.Transporters are a class of functional membrane proteins and control the movement of substances into or out of cells.Transporters,which are extensively expressed in the liver,play important roles in the drug hepatic disposition by regulating the uptake of drugs from blood into hepatocytes or the efflux of drugs and their metabolites into bile.In this review,the localization,functions and substrate selectivity of the major transporters in the liver will be summarized,and the impacts of these transporters on drug hepatic disposition,the potential drug-drug interactions as well as their genetic polymorphisms will also be reviewed. |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4524778 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267843]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Zhong Dafang |
| 作者单位 | Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Gao Chunying,Chen Xiaoyan,Zhong Dafang. Role of transporters in hepatic drug disposition[J]. Acta Pharmaceutica Sinica,2012,47(5):565-572. |
| APA | Gao Chunying,Chen Xiaoyan,&Zhong Dafang.(2012).Role of transporters in hepatic drug disposition.Acta Pharmaceutica Sinica,47(5),565-572. |
| MLA | Gao Chunying,et al."Role of transporters in hepatic drug disposition".Acta Pharmaceutica Sinica 47.5(2012):565-572. |
入库方式： OAI收割
来源：上海药物研究所
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