Determination of Zaltoprofen in Human Plasma by LC-MS/MS
文献类型：期刊论文
| 作者 | QIAN Yingmei1; ZHAN Yan3 ; ZHANG Yifan3; WEN Aidong2; ZHONG Dafang1
|
| 刊名 | Chinese Journal of Pharmaceuticals
 |
| 出版日期 | 2011 |
| 卷号 | 42期号:8页码:618-621 |
| 关键词 | zaltoprofen LC-MS/MS pharmacokinetics |
| ISSN号 | 1001-8255 |
| 其他题名 | 人血浆中扎托布洛芬的LC-MS/MS法测定 |
| 文献子类 | Article |
| 英文摘要 | An LC-MS/MS method was established for the determination of zaltoprofen in human plasma.A C_(18)column was used with the mobile phase of methanol-5 mmol/L ammonium acetate solution (70:30)and rosuvastatin calcium as internal standard.A tandem mass spectrometer equipped with electrospray ionization source was used as the detector and operated in the negative ion mode.The calibration curve was linear in the concentration range of 0.02 -8 mug/ml.The inter- and intra-day RSDs were less than 15% with extraction recoveries of 77.5% - 87.6%.A single oral dose of 80 mg zaltoprofen was administered to 24 healthy volunteers.The main pharmacokinetic parameters were as follows:C_(max)(4.161.46)mug/ml,t_(max)(1.541.00)h,t_(1/2)(3.891.69)h,A UC_(o-)(15.203.01)mug·h·ml~(-1). |
| WOS研究方向 | Pharmacology & Pharmacy ; Chemistry (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4298209 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267875]  |
| 专题 | 上海药物代谢研究中心 |
| 作者单位 | 1.Zhejiang University of Technology, Hangzhou, Zhejiang 310014, China.; 2.Xijing Hospital of Fourth Military Medical University, Xi'an, Shaanxi 710032, China. 3.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | QIAN Yingmei,ZHAN Yan,ZHANG Yifan,et al. Determination of Zaltoprofen in Human Plasma by LC-MS/MS[J]. Chinese Journal of Pharmaceuticals,2011,42(8):618-621. |
| APA | QIAN Yingmei,ZHAN Yan,ZHANG Yifan,WEN Aidong,&ZHONG Dafang.(2011).Determination of Zaltoprofen in Human Plasma by LC-MS/MS.Chinese Journal of Pharmaceuticals,42(8),618-621. |
| MLA | QIAN Yingmei,et al."Determination of Zaltoprofen in Human Plasma by LC-MS/MS".Chinese Journal of Pharmaceuticals 42.8(2011):618-621. |
入库方式： OAI收割
来源：上海药物研究所
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