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Research progress about the regulation of GXXXG structures in the Alzheimer-related protein

文献类型：期刊论文

作者Wu Yanlin2; Xin Xiaojie3; Xin Xianliang1; Geng Meiyu2
刊名Chinese Pharmacological Bulletin
出版日期2011
卷号27期号:1页码:1-4
关键词GXXXG structure Abeta production Abeta aggregation Alzheimer's disease APP gamma-secretase complex
ISSN号1001-1978
其他题名GXXXG结构对老年性痴呆相关蛋白功能调节研究进展
文献子类Review
英文摘要As a key factor of Alzheimer's disease(AD),beta-amyloid(Abeta)has emerged as an attractive drug target. Abeta species produced inhibitor is one of the most important aspects in anti-AD drug research and developement. Recent advances showed that some Abeta-related proteins, including beta-amyloid precursor protein(APP),gamma-secretase complex PS-1 and APH-1, have a special structure in transmembrane sequence(TMS),an amino-acid motif GXXXG, which has a regulatory impact on Abeta species production and aggregation. This paper describes the regulation of GXXXG structure to the function of AD-related proteins, which may hold the promise for the development of anti-AD drugs
资助项目国家杰出青年科学基金资助项目[00000000]
WOS研究方向General & Internal Medicine ; Neurosciences & Neurology ; Pharmacology & Pharmacy (provided by Clarivate Analytics)
语种中文
CSCD记录号CSCD:4128512
源URL[http://119.78.100.183/handle/2S10ELR8/267895]  
专题药理学第一研究室
通讯作者Geng Meiyu
作者单位1.Division of Anti-tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201023, China.
2.School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.;
3.Weifang Medical University, Weifang, Shandong 261053, China.;
推荐引用方式
GB/T 7714		 Wu Yanlin,Xin Xiaojie,Xin Xianliang,et al. Research progress about the regulation of GXXXG structures in the Alzheimer-related protein[J]. Chinese Pharmacological Bulletin,2011,27(1):1-4.
APA Wu Yanlin,Xin Xiaojie,Xin Xianliang,&Geng Meiyu.(2011).Research progress about the regulation of GXXXG structures in the Alzheimer-related protein.Chinese Pharmacological Bulletin,27(1),1-4.
MLA Wu Yanlin,et al."Research progress about the regulation of GXXXG structures in the Alzheimer-related protein".Chinese Pharmacological Bulletin 27.1(2011):1-4.

入库方式： OAI收割

来源：上海药物研究所

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