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Metabolites of injected chlorogenic acid in rats
文献类型：期刊论文
| 作者 | Xie Cen ; Zhong Dafang; Chen Xiaoyan
|
| 刊名 | Acta Pharmaceutica Sinica
 |
| 出版日期 | 2011 |
| 卷号 | 46期号:1页码:88-95 |
| 关键词 | UPLC/Q-TOFMS chlorogenic acid UPLC/Q-TOF MS metabolite GSH conjugate |
| ISSN号 | 0513-4870 |
| 其他题名 | 鉴定大鼠注射绿原酸后体内的代谢产物 |
| 文献子类 | Article |
| 英文摘要 | Chlorogenic acid(5-CQA) is one of the major components in some Chinese herbal injections. However, the metabolism of 5-CQA in rats after intravenous injection has not been determined. An ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry(UPLC/Q-TOF MS) method was applied to identify the metabolites in bile, urine, feces and plasma after a single intravenous administration of 10 mg·kg-1 5-CQA to rats. Using MSE and mass defect filter techniques,a total of 35 metabolites were detected in bile, urine, feces and plasma. The predominant metabolites in bile were glutathione conjugates of O-methyl-5-CQA, accounting for approximately 80% of the metabolites excreted in bile. The major components in urine were parent drug,O-methyl-5-CQA, hydrolyzed metabolites and glucuronide conjugates. The major components in feces were O-methyl-5-CQA and its cysteine conjugates. The major component in plasma was the parent drug. The urinary and fecal excretion pathways were equally important to 5-CQA in rats. These results demonstrate that 5-CQA undergoes extensively metabolism in rats and are highly reactive to nucleophiles such as GSH. This finding indicates that attention should be paid on the injections containing 5-CQA, which may covalently bind to proteins, leading to allergenic drug reactions |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4115247 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267898]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | Chen Xiaoyan |
| 作者单位 | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Xie Cen,Zhong Dafang,Chen Xiaoyan. Metabolites of injected chlorogenic acid in rats[J]. Acta Pharmaceutica Sinica,2011,46(1):88-95. |
| APA | Xie Cen,Zhong Dafang,&Chen Xiaoyan.(2011).Metabolites of injected chlorogenic acid in rats.Acta Pharmaceutica Sinica,46(1),88-95. |
| MLA | Xie Cen,et al."Metabolites of injected chlorogenic acid in rats".Acta Pharmaceutica Sinica 46.1(2011):88-95. |
入库方式： OAI收割
来源：上海药物研究所
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