Comparison the pharmacokinetics of tacrolimus in Chinese kidney transplant pa-tients after repeated-dose of modified release and immediate release preparations
文献类型：期刊论文
| 作者 | ZHANG Yi-fan2 ; CHEN Xiao-yan2; DAI Xiao-jian2; AO Jian-hua1; ZHONG Da-fang2
|
| 刊名 | The Chinese Journal of Clinical Pharmacology
 |
| 出版日期 | 2011 |
| 卷号 | 27期号:9页码:696-700 |
| 关键词 | modified release tacrolimus pharmacokinetics kidney transplantation |
| ISSN号 | 1001-6821 |
| 其他题名 | 比较他克莫司缓释制剂与普通制剂在中国肾移植患者的药代动力学 |
| 文献子类 | Article |
| 英文摘要 | Objective To compare the pharmacokinetics of tacrolimus in kidney transplant patients treated with modified release and immediate release preparations.Methods It was a multi-centre，open label，1∶1 randomized，parallel，repeated-dose study.Adult kidney transplant recipients aged from 18-70 years were randomized into modified release group once daily(qd)and immediate release group twice a day(bid)． A validated LC/MS/MS method was used to determine blood concentrations of tacrolimus.Results The mean daily dose for modified release (n=17)was(0.120.05)mg·kg~(-1)on day 56，and that for immediate release(n=15)was(0.100.04)mg·kg~(-1).The parameters of tacrolimus for the two formulations at steady state were as follows:C_(max) was(13.204.20)ng·mL~(-1) at(3.103.00)h for modified release and(11.803.80)ng·mL~(-1) at(1.800.90)h for immediate release，C_(24)was(4.401.30)and(4.501.20)ng·mL~(-1)，and AUC0-24 was(171.7049.90)and(145.1029.30)ng·mL~(-1)·h， respectively.The coefficient between AUC0-24 and C24 was 0.87 for modified release，and was 0.62 for immediate release，respectively.Conclusion In patients undergoing primary kidney transplantation，daily dose of modified release tacrolimus increases 23%compared with that of immediate release on day 56 after operation，and the systemic exposure to tacrolimus over the 24-hour interval is 16%higher.There is a good correlation between C_(24) and AUC(0-24) for the modified release tacrolimus. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4315316 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267900]  |
| 专题 | 上海药物代谢研究中心 |
| 通讯作者 | ZHONG Da-fang |
| 作者单位 | 1.The Gen-eral Hospital of the People's Liberation Army, Beijing 100853, China. 2.Shanghai Institute of Material Medica,Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | ZHANG Yi-fan,CHEN Xiao-yan,DAI Xiao-jian,et al. Comparison the pharmacokinetics of tacrolimus in Chinese kidney transplant pa-tients after repeated-dose of modified release and immediate release preparations[J]. The Chinese Journal of Clinical Pharmacology,2011,27(9):696-700. |
| APA | ZHANG Yi-fan,CHEN Xiao-yan,DAI Xiao-jian,AO Jian-hua,&ZHONG Da-fang.(2011).Comparison the pharmacokinetics of tacrolimus in Chinese kidney transplant pa-tients after repeated-dose of modified release and immediate release preparations.The Chinese Journal of Clinical Pharmacology,27(9),696-700. |
| MLA | ZHANG Yi-fan,et al."Comparison the pharmacokinetics of tacrolimus in Chinese kidney transplant pa-tients after repeated-dose of modified release and immediate release preparations".The Chinese Journal of Clinical Pharmacology 27.9(2011):696-700. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。