LC-UV/MSn analysis of related impurities of griseofulvin
文献类型：期刊论文
| 作者 | DU Yue2; YANG Huiyuan2; DENG Pan1; LIU Hao2; CHEN Xiaoyan1
|
| 刊名 | Chinese Journal of Pharmaceutical Analysis
 |
| 出版日期 | 2011 |
| 卷号 | 31期号:8页码:1475-1479 |
| 关键词 | antibiotic griseofulvin impurities LC-UV/ion trap mass spectrometry |
| ISSN号 | 0254-1793 |
| 其他题名 | 液相色谱-紫外光谱-离子阱质谱法分析灰黄霉素中的相关杂质 |
| 文献子类 | Article |
| 英文摘要 | Objective:To develop an LC-UV/MS method for analysis of impurities of griseofulvin.Methods:Reversed-phase gradient chromatography was used to separate griseofulvin solution,which was detected by UV detector.The major impurities were identified by ion trap mass spectrometry equipped with ESI source in the positive ion mode.Results:Six impurities of griseofulvin,including dechlorgriseofulvin,dehydrogriseofulvin,isogriseofulvin,griseofulvic acid,4-demethylgriseofulvin and 6-demethylgriseofulvin were identified.Conclusion:The new developed method for the analysis of the related impurities in griseofulvin is useful to control the quality of griseofulvin. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:4312623 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267912]  |
| 专题 | 上海药物代谢研究中心 |
| 作者单位 | 1.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China. 2.Shanghai Institute for Food and Drug Control, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | DU Yue,YANG Huiyuan,DENG Pan,et al. LC-UV/MSn analysis of related impurities of griseofulvin[J]. Chinese Journal of Pharmaceutical Analysis,2011,31(8):1475-1479. |
| APA | DU Yue,YANG Huiyuan,DENG Pan,LIU Hao,&CHEN Xiaoyan.(2011).LC-UV/MSn analysis of related impurities of griseofulvin.Chinese Journal of Pharmaceutical Analysis,31(8),1475-1479. |
| MLA | DU Yue,et al."LC-UV/MSn analysis of related impurities of griseofulvin".Chinese Journal of Pharmaceutical Analysis 31.8(2011):1475-1479. |
入库方式： OAI收割
来源：上海药物研究所
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