Preparation of Daidzein-Phospholipid Complex and Its Bioavailability Study in Rats
文献类型：期刊论文
| 作者 | Huang Yan1; Gu Wangwen2 ; Gao Zhiwei2; Zhang Zhiwen2
|
| 刊名 | Chinese Journal of Modern Applied Pharmacy
 |
| 出版日期 | 2010 |
| 卷号 | 27期号:7页码:618-622 |
| 关键词 | daidzein phospholipid complex apparent solubility bioavailability |
| ISSN号 | 1007-7693 |
| 其他题名 | 黄豆苷元磷脂复合物的制备及大鼠体内生物利用度的研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To optimize preparation methods of daidzein-phospholipid complex and determine its bioavailability in rats after oral administration. METHODS Using binding ratio of daidzein to phospholipid as evaluation parameter, the preparation methods for daidzein-phospholipid complex were optimized by means of single factor tests and orthogonal design. Apparent solubility of daidzein, physical mixture and daidzein-phospholipid complex in water and n-octanol was determined, respectively. The concentrations of daidzein in plasma samples in rats were analysed by LC-MS/MS after oral administration of daidzein suspension, physical mixture and daidzein-phospholipid complex, and their bioavailabilities were compared. RESULTS The daidzein-phospholipid complex was prepared by stirring and refluxing phospholipid Epikuron 200 and daidzein (molar ratio 1.5:1) in ethanol at a temperature of 60 ℃ for 2 h. Apparent solubility of daidzein-phospholipid complex were 3.1 and 5.4 folds compared with daidzein in water and n-octanol, respectively. Pharmacokinetic parameters of C_(max) were (66765) ng·mL~(-1) and (7 509688)ng·mL~(-1), T_(max) were (3.000.82)h and (0.420.17)h,AUC_(0-) were (8 302590)ng·h·mL~(-1) and (28 870 2 411)ng·h·mL~(-1) after oral administration of daidzein suspension and daidzein-phospholipid complex in rats, respectively. The relative bioavailability of daidzeinphospholipid complex to daidzein was 3.48. CONCLUSION Apparent solubility of daidzeinphospholipid complex both in water and n-octanol were improved, thus, increasing gastrointestinal absorption. As a result, the bioavailability was increased after oral administration of daidzein-phospholipid complex in rats |
| 资助项目 | 国家自然科学基金资助项目[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3997758 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267925]  |
| 专题 | 药物制剂研究中心 上海药物代谢研究中心 |
| 作者单位 | 1.School of Pharmacy, Jiangsu University, Zhenjiang, Jiangsu 212013, China.; 2.Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
| 推荐引用方式 GB/T 7714 | Huang Yan,Gu Wangwen,Gao Zhiwei,et al. Preparation of Daidzein-Phospholipid Complex and Its Bioavailability Study in Rats[J]. Chinese Journal of Modern Applied Pharmacy,2010,27(7):618-622. |
| APA | Huang Yan,Gu Wangwen,Gao Zhiwei,&Zhang Zhiwen.(2010).Preparation of Daidzein-Phospholipid Complex and Its Bioavailability Study in Rats.Chinese Journal of Modern Applied Pharmacy,27(7),618-622. |
| MLA | Huang Yan,et al."Preparation of Daidzein-Phospholipid Complex and Its Bioavailability Study in Rats".Chinese Journal of Modern Applied Pharmacy 27.7(2010):618-622. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。