Pharmacokinetic Studies of Misoprostol Tablet Following Oral, Sublingual and Vaginal Administration in Female Volunteers
文献类型：期刊论文
| 作者 | WU Gao-lei2; PEI Kai-yan1; CHEN Xiao-yan2 ; ZHANG Yi-fan2; ZHONG Da-fang2; JIA Meng-chun1
|
| 刊名 | Chinese Pharmaceutical Journal
 |
| 出版日期 | 2010 |
| 卷号 | 45期号:1页码:52-56 |
| 关键词 | misoprostol administration route liquid chromatography-tandem mass spectrometry pharmaeokinetics |
| ISSN号 | 1001-2494 |
| 其他题名 | 米索前列醇片不同给药途径的人体药动学研究 |
| 文献子类 | Article |
| 英文摘要 | OBJECTIVE To compare the pharmacokinetic profiles of orally, sublingually, and vaginally administered misoprostol tablets in Chinese healthy female volunteers. METHODS A total of 30 women were randomized to receive 400 mu g of misoprostol by one of three routes: (ⅰ) oral (ⅱ) sublingual (ⅲ) vaginal. The major active metabolite of misoprostol acid was determined in plasma u-sing a liquid chromatographic-tandem mass spectrometric method. RESULTS The main pharmacokinetic parameters of misoprostol acid administered by oral, sublingual and vaginal routes were as follows: t_(max)(0. 18 0. 05), (0. 40 0. 14) and (5. 05 1. 80) h, rho_(max)(1424380), (783285) and (302198) ng · L~(-1), t_(1/2)(0.61 0.32), (0.820.18) and (5.274.38) h, AUC_(0-t) (698 138), (824 302) and (1 313 691) ng · h · L~(-1), AUC_(0-) (709 143), (846 306) and (1 816 727) ng · h · L~(-1), respectively. CONCLUSION There are significant differences in the pharmaeokinetics of misoprostol administered by oral, vaginal and sublingual routes. Oral misoprostol had a higher peak plasma concentration of misoprostol acid and a shorter duration to maximum concentration than either sublingual or vaginal misoprostol. rho_(max) obtained after vaginal administration is the lowest, but the AUC is significantly higher than those in the oral and sublingual groups. However, there was a wide individual variability in the vaginal group. |
| 资助项目 | 国家科技支撑计划课题[00000000] |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3810243 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267929]  |
| 专题 | 上海药物代谢研究中心 |
| 作者单位 | 1.National Research Institute for Family Planning, Beijing 100081, China. 2.Shanghai Institute of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.; |
| 推荐引用方式 GB/T 7714 | WU Gao-lei,PEI Kai-yan,CHEN Xiao-yan,et al. Pharmacokinetic Studies of Misoprostol Tablet Following Oral, Sublingual and Vaginal Administration in Female Volunteers[J]. Chinese Pharmaceutical Journal,2010,45(1):52-56. |
| APA | WU Gao-lei,PEI Kai-yan,CHEN Xiao-yan,ZHANG Yi-fan,ZHONG Da-fang,&JIA Meng-chun.(2010).Pharmacokinetic Studies of Misoprostol Tablet Following Oral, Sublingual and Vaginal Administration in Female Volunteers.Chinese Pharmaceutical Journal,45(1),52-56. |
| MLA | WU Gao-lei,et al."Pharmacokinetic Studies of Misoprostol Tablet Following Oral, Sublingual and Vaginal Administration in Female Volunteers".Chinese Pharmaceutical Journal 45.1(2010):52-56. |
入库方式： OAI收割
来源：上海药物研究所
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