New advances in isoform-selective inhibitors of Zn~(2+)-dependent histone deacetylase
文献类型：期刊论文
| 作者 | Liu Hongchun2 ; Du Xiaoguang1; Geng Meiyu2
|
| 刊名 | Chinese Pharmacological Bulletin
 |
| 出版日期 | 2010 |
| 卷号 | 26期号:8页码:985-989 |
| 关键词 | histone deacetylase Zn~(2+)-dependent histone deacetylase isoform-selective inhibitor pan-inhibitor toxicity tumor |
| ISSN号 | 1001-1978 |
| 其他题名 | 锌依赖的组蛋白去乙酰化酶选择性抑制剂研究进展 |
| 文献子类 | Review |
| 英文摘要 | Histone deacetylases (HDACs) have emerged as attractive drug targets. This large family consists of 18 enzymes. These isoforms have generally distinct gene expression patterns and are also different in cellular localization and function. Therefore the pan-inhibitors exhibited toxicities in the clinic that might limit their potential, particularly in solid tumors. It may be possible to reduce the toxicity by selectively targeting only the specific isoform(s) involved in maintaining one particular tumor and not affecting other isoforms that are uninvolved or even beneficial. And this opinion has become a more promising strategy. The current existing HDAC selective-inhibitors mainly target HDAC 1, 2,6,8. In this review the developing trend of HDAC inhibitor and the studies about HDAC selective-inhibitors are presented |
| 资助项目 | 国家杰出青年科学基金资助项目[00000000] |
| WOS研究方向 | General & Internal Medicine ; Oncology ; Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3977059 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/267940]  |
| 专题 | 药理学第一研究室 |
| 通讯作者 | Geng Meiyu |
| 作者单位 | 1.Division of Anti-tumor Pharmacology, State Key Laboratory of Durg Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201023, China. 2.School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China.; |
| 推荐引用方式 GB/T 7714 | Liu Hongchun,Du Xiaoguang,Geng Meiyu. New advances in isoform-selective inhibitors of Zn~(2+)-dependent histone deacetylase[J]. Chinese Pharmacological Bulletin,2010,26(8):985-989. |
| APA | Liu Hongchun,Du Xiaoguang,&Geng Meiyu.(2010).New advances in isoform-selective inhibitors of Zn~(2+)-dependent histone deacetylase.Chinese Pharmacological Bulletin,26(8),985-989. |
| MLA | Liu Hongchun,et al."New advances in isoform-selective inhibitors of Zn~(2+)-dependent histone deacetylase".Chinese Pharmacological Bulletin 26.8(2010):985-989. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。