Pharmacodynamics and pharmacokinetics of SHR115723,a novel tyrosine kinase inhibitor
文献类型：期刊论文
| 作者 | Xiao L(肖亮)2; Gong AS(宫爱申)2; Bie PY(别平彦)2; Lou LG(楼丽广)1 ; Deng BC(邓炳初)2
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| 刊名 | Chinese Journal of New Drugs and Clinical Remedies
 |
| 出版日期 | 2008 |
| 卷号 | 27期号:8页码:561-565 |
| 关键词 | SHR115723 sunitinib tumor pharmacokinetics tyrosine kinase receptors SHR115723 |
| ISSN号 | 1007-7669 |
| 其他题名 | 酪氨酸激酶抑制药SHR115723的药效学及药动学 |
| 文献子类 | Article |
| 英文摘要 | AIM To evaluate the pharmacodynamics and pharmacokinetics of SHR115723 in comparison with those of sunitinib in vitro and in vivo,to determine the prospects of SHR115723 for new drug development. METHODS The growth inhibitory effects of the compounds on human umbilical vein endothelial cells (HUVEC)were determined by sulforhodamine B assay in vitro.Murine xenograft model of HT-29 human colon cancer was developed to evaluate the antitumor effects of the compounds in vivo.High performance liquid chromatography plus ultraviolet detector were used in the pharmacokinetics study of the compounds in rats. RESULTS The IC_(50)of the growth inhibitory effects for SHR115723 and sunitinib on HUVEC were(1.3s 0.3) and(0.780.23)mumol·L~(-1),respectively.Significant growth inhibitory effects of SHR115723 and sunitinib on HT-29 tumor were observed in mice.The A UC and c_(max)of SHR115723 were better than those of sunitinib in rats, but SHR115723 had a smaller distribution volume than sunitinib.CONCLUSION SHR115723 has remarkable antitumor effects and better pharmacokinetics characteristics,and could be an attractive target for new drug development. |
| WOS研究方向 | Pharmacology & Pharmacy (provided by Clarivate Analytics) |
| 语种 | 中文 |
| CSCD记录号 | CSCD:3357432 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/268047]  |
| 专题 | 药理学第一研究室 |
| 作者单位 | 1.中国科学院上海生命科学院,上海药物研究所, 上海 201203, 中国. 2.上海恒瑞医药有限公司, 上海 200245, 中国.; |
| 推荐引用方式 GB/T 7714 | Xiao L,Gong AS,Bie PY,et al. Pharmacodynamics and pharmacokinetics of SHR115723,a novel tyrosine kinase inhibitor[J]. Chinese Journal of New Drugs and Clinical Remedies,2008,27(8):561-565. |
| APA | 肖亮,宫爱申,别平彦,楼丽广,&邓炳初.(2008).Pharmacodynamics and pharmacokinetics of SHR115723,a novel tyrosine kinase inhibitor.Chinese Journal of New Drugs and Clinical Remedies,27(8),561-565. |
| MLA | 肖亮,et al."Pharmacodynamics and pharmacokinetics of SHR115723,a novel tyrosine kinase inhibitor".Chinese Journal of New Drugs and Clinical Remedies 27.8(2008):561-565. |
入库方式： OAI收割
来源：上海药物研究所
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